Gastroprotective effects (in rodents) of a flavonoid rich fraction obtained from Syngonanthus macrolepsis
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Data
2014-03-01
Autores
Batista, Leonia Maria
Albino de Almeida, Ana Beatriz
Morais Lima, Gedson Rodrigues de
Falcao, Heloina de Sousa
Magri, Luciana de Pietro
Luiz-Ferreira, Anderson
Santos, Lourdes Campaner dos [UNESP]
Hiruma-Lima, Clelia Akiko [UNESP]
Vilegas, Wagner [UNESP]
Monteiro Souza Brito, Alba Regina
Título da Revista
ISSN da Revista
Título de Volume
Editor
Wiley-Blackwell
Resumo
Objectives: Syngonanthus macrolepis, popularly known in Brazil as sempre-vivas', is a plant from the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. The species contains a variety of constituents, including flavonoids with gastroprotective effect. In this work, a flavonoid-rich fraction (Sm-FRF) obtained from scapes of S.macrolepis was investigated for preventing gastric ulceration in mice and rats.MethodsThe activity was evaluated in models of induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs and pylorus ligation). The cytoprotective mechanisms of the Sm-FRF in relation to sulfhydryl (SH) groups, nitric oxide (NO) and antioxidant enzymes were also evaluated.Key findingsThe Sm-FRF (100mg/kg, p.o.) significantly reduced gastric injury in all models, and did not alter gastric juice parameters after pylorus ligation.ConclusionsThe results indicate significant gastroprotective activity for the Sm-FRF, which probably involves the participation of both SH groups and the antioxidant system. Both are integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors.
Descrição
Palavras-chave
Eriocaulaceae, flavonoid, gastroprotective activity, medicinal plants, Syngonanthus macrolepsis
Como citar
Journal Of Pharmacy And Pharmacology. Hoboken: Wiley-blackwell, v. 66, n. 3, p. 445-452, 2014.