Simvastatin Does Not Reduce Chemokine Production in Obesity Without Comorbidities
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Data
2015-06-01
Autores
Fernandes, Karla Silva
Bela, Samantha Ribeiro
Andrade, Vanessa L.
Moraes, Tatiane Figueiredo de
Martins-Filho, Olindo de Assis
Sandrim, Valeria Cristina [UNESP]
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Editor
Springer
Resumo
Obesity is considered a subchronic inflammatory disease with high risk of comorbidity development. Obesity-associated inflammation originates from adipose tissue itself, which secretes a panel of inflammatory chemokines and cytokines. Therefore, we enrolled 23 obese women without comorbidity and evaluated if simvastatin 20 mg/day dose therapy for 6 weeks (n=15) may modulate plasma levels of inflammatory CXCL-10, CCL-2, CXCL-9, CXCL-8, and CCL-5. A significant decrease of cholesterol and its fractions, triglycerides, and high-sensitivity C-reactive protein (hsCRP) after simvastatin treatment was observed when compared to placebo (n=8). Chemokine plasma levels were unchanged by statin intake when compared to placebo. Although dyslipidemia biomarkers and hsCRP have been diminished by simvastatin, low chemokine amounts produced by healthy obese women do not seem to be altered by simvastatin anti-inflammatory activity.
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Palavras-chave
chemokines, statins, women, plasma, healthy obese
Como citar
Inflammation, v. 38, n. 3, p. 1297-1301, 2015.