Development and validation of the quantitative analysis of cefuroxime sodium in powder for injection by infrared spectroscopy
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Data
2012
Autores
Vieira, Daniela Cristina de Macedo [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Scientific & Academic Publishing
Resumo
Ceftazidime quantification by the infrared spectroscopy was developed and validated for pharmaceutical preparations in powder for injection. This method involved absorbance measurements of the band corresponding to aromatic ring centered by 1475-1600 cm-1. Selectivity, linearity, precision and accuracy were determined in order to validate the proposed method. It was also found that the excipient did not interfere with the assay. Calibration curve was obtained for ceftazidime at 0.5 to 7.0 mg, and mean recovery percentage was 98.98 ± 0.70. The proposed method was successfully applied to the assay of ceftazidime in powder for injection.
Descrição
Palavras-chave
Ceftazidime, Infrared, Spectroscopy, Quantitative, Determination
Como citar
Advances in Analytical Chemistry, v. 2, n. 6, p. 80-87, 2012.