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dc.contributor.authorSilva, Leopoldo Muniz da [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.authorTakaku, Mariana [UNESP]
dc.contributor.authorMizubuti, Glênio Bittencourt [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.date.accessioned2016-07-07T12:33:19Z
dc.date.available2016-07-07T12:33:19Z
dc.date.issued2013
dc.identifierhttp://dx.doi.org/10.4236/ojneph.2013.34032
dc.identifier.citationOpen Journal of Nephrology, v. 3, n. 4, p. 184-188, 2013.
dc.identifier.issn2164-2842
dc.identifier.urihttp://hdl.handle.net/11449/140326
dc.description.abstractIntroduction: The utility of estimates of glomerular filtration rate based on creatinine and cystatin C serum levels to assess renal function in older surgical patients remains to be determined. Objective: To determine whether 2h-creatinine clearance (CrCl-2h) can be an adequate substitute for glomerular filtration rate estimates obtained by measuring serum cystatin C and creatinine in the elderly at preoperation. Methods: A total of 102 consecutive elder patients undergoing pre-anesthesia evaluation for routine surgeries were included. Study subjects were allocated into three groups: Group 1 (G1)—hypertensive diabetic patients, Group 2 (G2)—hypertensive patients, and Group 3 (G3)—non-hypertensive and non-diabetic patients. Two-hour urine collection was performed and CrCl-2h adjusted for ultrasonic residual bladder volume was estimated. GFR was estimated based on creatinine and cystatin C serum levels. Bland-Altman analysis was used to compare methods. Results: The mean difference between the evaluated methods and CrCl-2h was <15 mL·min−1 ·1.73 m−2 for Cys-GFR, and >20 mL·min−1 ·1.73 m−2 for Cr-GFR in all groups. CrCl-2h adjusted for ultrasonic residual bladder volume did not differ from non-adjusted CrCl-2h in none of the groups. Conclusion: Two-hour creatinine clearance was not an adequate substitute for GFR estimates based on creatinine and cystatin C serum levels in older patients at preoperation. The ultrasonic assessment of residual bladder volume had no significant influence on the calculation of two-hour creatinine clearance.en
dc.format.extent184-188
dc.language.isoeng
dc.relation.ispartofOpen Journal of Nephrology
dc.sourceCurrículo Lattes
dc.subjectRenal functionen
dc.subjectCreatinine clearanceen
dc.subjectCystatin Cen
dc.subjectElderlyen
dc.titleTwo-hour creatinine clearance and glomerular filtration rate estimated from serum cystatin C and creatinine in the elderly to preoperative perioden
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Anestesiologia, Faculdade de Medicina de Botucatu
dc.identifier.doi10.4236/ojneph.2013.34032
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.fileISSN2164-2842-2013-03-04-184-188.pdf
unesp.departmentAnestesiologiapt
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