Histomorphometric analysis of the repair process of autogenous bone grafts fixed at rat calvaria with cyanoacrylate
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Data
2011-09-01
Autores
Esteves, Jonatas Caldeira [UNESP]
Borrasca, Albanir Gabriel
Aranega, Alessandra Marcondes [UNESP]
Garcia Junior, Idelmo Rangel [UNESP]
Magro Filho, Osvaldo [UNESP]
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Editor
Universidade de São Paulo (USP), Faculdade de Odontologia de Bauru
Resumo
Objective: The purpose of this study was to perform histological and histometric analyses of the repair process of autogenous bone grafts fixed at rat calvaria with ethyl-cyanoacrylate adhesive. Material and Methods: Thirty-two rats were divided into two groups (n=16), Group I - Control and Group II - Adhesive. Osteotomies were made at the right parietal bone for graft obtainment using a 4-mm-diameter trephine drill. Then, the bone segments were fixed with the adhesive in the parietal region of the opposite side to the donor site. After 10 and 30 days, 8 animals of each group were euthanized and the calvarias were laboratorially processed for obtaining hematoxylin and eosin-stained slides for histological and histometric analyses. Results: An intense inflammatory reaction was observed at the 10-day period. At 30 days, this reaction was less intense, despite the presence of adhesive at the recipient-site/graft interface. Graft incorporation to the recipient site was observed only at the control group, which maintained the highest graft size at 10 and 30 days. Conclusions: Although the fragment was stable, the presence of adhesive in Group II did not allow graft incorporation to the recipient site, determining a localized, discrete and persistent inflammatory reaction.
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Palavras-chave
Tissue adhesives, Cyanoacrylates, Bone transplantation
Como citar
Journal of Applied Oral Science. Bauru-sp: Univ São Paulo Fac Odontologia Bauru, v. 19, n. 5, p. 529-534, 2011.