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dc.contributor.authorDe Luca, L. A.
dc.contributor.authorSugawara, A. M.
dc.contributor.authorPereira, DTB
dc.contributor.authorDavid, R. B.
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.date.accessioned2014-05-20T13:45:45Z
dc.date.available2014-05-20T13:45:45Z
dc.date.issued2002-03-22
dc.identifierhttp://dx.doi.org/10.1016/S0006-8993(01)03202-4
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 931, n. 1, p. 1-4, 2002.
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/11449/16122
dc.description.abstractCalcium channels mediate the actions of many drugs. The present work investigated whether diltiazem, an L-type calcium channel blocker, alters the inhibition of sodium appetite induced by noradrenaline and the alpha(2)-adrenoceptor agonist clonidine. Adult male Holtzman rats (N=4-8) with cannula implanted into the third cerebral ventricle were submitted to sodium depletion {furosemide sc+24-h removal of ambiente sodium). Sodium depleted control animals that received 0.9% NaCl as vehicle injected intracerebroventricularly (i.c.v) ingested 13.0+/-1.5 ml/120 min of 1.8% NaCl. Intracerebroventricular injection of either noradrenaline (80 nmol) or clonidine (20 nmol) inhibited 1.8% NaCl intake from 70 to 90%. Prior i.c.v. injection of diltiazem (6-48 nmol) inhibited from 50 to 100% the effect of noradrenaline and clonidine in a dose-response manner. Diltiazem alone at 100 nmol inhibited, but at 50 nmol had no effect on, sodium appetite. The results suggest: (1) common ionic mechanisms involving calcium channels for the inhibition that noradrenaline and clonidine exert on sodium appetite and (2) a dual role for the benzothiazepine site of L-type calcium channels in the control of sodium appetite. (C) 2002 Elsevier B.V. B V. All rights reserved.en
dc.format.extent1-4
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBrain Research
dc.sourceWeb of Science
dc.subjectdiltiazempt
dc.subjectclonidinept
dc.subjectnoradrenalinept
dc.subjectdehydrationpt
dc.subjectsodium depletionpt
dc.subjectsalt intakept
dc.titleInteraction between brain L-type calcium channels and alpha(2)-adrenoceptors in the inhibition of sodium appetiteen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.description.affiliationUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil
dc.identifier.doi10.1016/S0006-8993(01)03202-4
dc.identifier.wosWOS:000174777100001
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt
dc.identifier.lattes1023597870118105
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0001-5677-1670[4]
unesp.author.orcid0000-0003-1167-4441[5]
unesp.author.orcid0000-0001-8270-2652[1]
dc.relation.ispartofjcr3.125
dc.relation.ispartofsjr1,404
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