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dc.contributor.authorSugawara, A. M. [UNESP]
dc.contributor.authorMiguel, T. T. [UNESP]
dc.contributor.authorPereira, D. T. B. [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.authorLuca Junior, Laurival Antonio de [UNESP]
dc.date.accessioned2014-05-20T13:45:52Z
dc.date.available2014-05-20T13:45:52Z
dc.date.issued2001-09-01
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2001000900012
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 34, n. 9, p. 1185-1190, 2001.
dc.identifier.issn0100-879X
dc.identifier.urihttp://hdl.handle.net/11449/16178
dc.description.abstractNon-adrenergic ligands that bind to imidazoline receptors (I-R), a selective ligand that binds to alpha2-adrenoceptors (alpha2-AR) and mixed ligands that bind to both receptors were tested for their action on water intake behavior of 24-h water-deprived rats. All drugs were injected into the third cerebral ventricle. Except for agmatine (80 nmol), mixed ligands binding to I-R/alpha2-AR such as guanabenz (40 nmol) and UK 14304 (20 nmol) inhibited water intake by 65% and up to 95%, respectively. The selective non-imidazoline alpha2-AR agonist, alpha-methylnoradrenaline, produced inhibition of water intake similar to that obtained with guanabenz, but at higher doses (80 nmol). The non-adrenergic I-R ligands histamine (160 nmol, mixed histaminergic and imidazoline ligand) and imidazole-4-acetic acid (80 nmol, imidazoline ligand) did not alter water intake. The results show that selective, non-imidazoline alpha2-AR activation suppresses water intake, and suggest that the action on imidazoline sites by non-adrenergic ligands is not sufficient to inhibit water intake.en
dc.format.extent1185-1190
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica (ABRADIC)
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.sourceSciELO
dc.subjectimidazolinesen
dc.subjectagmatineen
dc.subjectUK 14304en
dc.subjectguanabenzen
dc.subjectalpha-methylnoradrenalineen
dc.subjectthirsten
dc.subjectdehydrationen
dc.titleEffects of central imidazolinergic and alpha2-adrenergic activation on water intakeen
dc.typeArtigo
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Estadual Paulista Faculdade de Odontologia Departamento de Fisiologia e Patologia
dc.description.affiliationUnespUniversidade Estadual Paulista Faculdade de Odontologia Departamento de Fisiologia e Patologia
dc.identifier.doi10.1590/S0100-879X2001000900012
dc.identifier.scieloS0100-879X2001000900012
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
dc.identifier.fileS0100-879X2001000900012.pdf
dc.identifier.lattes1023597870118105
dc.identifier.lattes339253755971890
unesp.author.lattes1023597870118105
unesp.author.lattes339253755971890
unesp.author.orcid0000-0001-8270-2652[5]
unesp.author.orcid0000-0003-1167-4441[4]
dc.relation.ispartofjcr1.492
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