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dc.contributor.authorGut, Ana Lúcia [UNESP]
dc.contributor.authorSugizaki, Mario Mateus [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.authorCarvalho, Robson Francisco [UNESP]
dc.contributor.authorDal Pai-Silva, Maeli [UNESP]
dc.contributor.authorAragon, Flávio Ferrari [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.date.accessioned2014-05-20T13:48:00Z
dc.date.available2014-05-20T13:48:00Z
dc.date.issued2008-10-01
dc.identifierhttp://dx.doi.org/10.1016/j.nutres.2008.06.001
dc.identifier.citationNutrition Research. Oxford: Pergamon-Elsevier B.V. Ltd, v. 28, n. 10, p. 722-727, 2008.
dc.identifier.issn0271-5317
dc.identifier.urihttp://hdl.handle.net/11449/17106
dc.description.abstractAlthough long-term food restriction (FR) has been shown to induce cardiac remodeling and dysfunction, there arc few data on the effects of FR on pressure-overloaded hearts. The aim of this study was to examine the effects of FR on cardiac muscle performance during inotropic stimulation in the myocardium of spontaneously hypertensive rats (SIIRs). Male 60-day-old SHRs were subjected to FR for 90 days. Food-restricted animals received 50% of the ad libitum amount of food consumed by the control group. Myocardial function was studied in isolated left ventricular papillary muscle tinder isometric contraction in basal condition (1.25 mmol/L extracellular Ca2+ concentration) and after 3 inotropic maneuvers: (1) at postrest contraction of 30 seconds, (2) at extraccllular Ca2+ concentration of 5.2 mmol/L, and (3) after beta-adrenergic stimulation with 10 (6) mol/L isoproterenol. At basal condition, little from peak tension to 50'% relaxation was greater in the food-restricted group (P <.05). Inotropic stimulation with postrest contraction and isoproterenol promoted a significant lower increase of developed tension, maximum rate of tension development, and maximum rate of tension decline in the food-restricted compared to the control group. The elevation of extraccllular Ca2+ concentration induced a lower increase of developed tension, maximum rate of tension development, and time from peak tension to 50'% relaxation in the food-restricted than in the control group. In conclusion, long-term FR promotes impairment of myocardial inotropic response to calcium and beta-adrenergic stimulation in SHRS. (C) 2003 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFaculty of Medicine, UNESP, Botucatu
dc.format.extent722-727
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofNutrition Research
dc.sourceWeb of Science
dc.subjectInotropic stimulationen
dc.subjectHypertrophyen
dc.subjectMyocardial contractilityen
dc.subjectSpontaneously hypertensive raten
dc.subjectUndernutritionen
dc.titleFood restriction impairs myocardial inotropic response to calcium and beta-adrenergic stimulation in spontaneously hypertensive ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationState Univ Julio Mesquita Filho UNESP, Dept Internal Med, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationState Univ Julio Mesquita Filho UNESP, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationState Univ Julio Mesquita Filho UNESP, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.description.affiliationUnespState Univ Julio Mesquita Filho UNESP, Dept Internal Med, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationUnespState Univ Julio Mesquita Filho UNESP, Biosci Inst, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnespState Univ Julio Mesquita Filho UNESP, Biosci Inst, Dept Biostat, Botucatu, SP, Brazil
dc.identifier.doi10.1016/j.nutres.2008.06.001
dc.identifier.wosWOS:000260291600010
dc.rights.accessRightsAcesso restrito
dc.description.sponsorshipIdFAPESP: 02/12314-5
dc.description.sponsorshipIdCNPq: 302502/2004-1
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
dc.identifier.lattes5406518799128485
dc.identifier.lattes5452093689066508
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.lattes4463138671998432
dc.identifier.lattes1590971576309420
dc.identifier.orcid0000-0002-4901-7714
unesp.author.lattes5406518799128485
unesp.author.lattes5452093689066508
unesp.author.lattes9418970103564137
unesp.author.lattes8727897080522289
unesp.author.lattes4463138671998432
unesp.author.lattes1590971576309420
unesp.author.orcid0000-0002-4901-7714[4]
dc.relation.ispartofjcr2.707
dc.relation.ispartofsjr1,135
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