Interrelationship between periapical lesion and systemic metabolic disorders
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Data
2016-04-01
Autores
Sasaki, Hajime
Hirai, Kimito
Martins, Christine M. [UNESP]
Furusho, Hisako
Battaglino, Ricardo
Hashimoto, Koshi
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Resumo
Background: Periapical periodontitis, also known as periapical lesion, is a common dental disease, along with periodontitis (gum disease). Periapical periodontitis is a chronic inflammatory disease, caused by endodontic infection, and its development is regulated by the host immune/inflammatory response. Metabolic disorders, which are largely dependent on life style such as eating habits, have been interpreted as a “metabolically-triggered” low-grade systemic inflammation and may interact with periapical periodontitis by triggering immune modulation. The host immune system is therefore considered the common fundamental mechanism of both disease conditions. Method: We have reviewed >200 articles to discuss the interrelationship between periapical lesions and metabolic disorders including type 2 diabetes mellitus, hypertension, and non-alcoholic fatty liver diseases (NAFLD), and their common pathological background in immunology/osteoimmunology and cytokine biology. Results: An elevated inflammatory state caused by metabolic disorders can impact the clinical outcome of periapical lesions and interfere with wound healing after endodontic treatment. Although additional well-designed clinical studies are needed, periapical lesions appear to affect insulin sensitivity and exacerbate non-alcoholic steatohepatitis. Conclusion: Immune regulatory cytokines produced by various cell types, including immune cells and adipose tissue, play an important role in this interrelationship.
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Cytokines, Hypertension, Immunity, Inflammation, Metabolic disorders, NAFLD, Periapical lesion, Type 2 diabetes
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Current Pharmaceutical Design, v. 22, n. 15, p. 2204-2215, 2016.