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dc.contributor.authorValões, C. C.M.
dc.contributor.authorMolinari, B. C.
dc.contributor.authorPitta, A. C.G.
dc.contributor.authorGormezano, N. W.S.
dc.contributor.authorFarhat, S. C.L.
dc.contributor.authorKozu, K.
dc.contributor.authorSallum, A. M.E.
dc.contributor.authorAppenzeller, S.
dc.contributor.authorSakamoto, A. P.
dc.contributor.authorTerreri, M. T.
dc.contributor.authorPereira, R. M.R.
dc.contributor.authorMagalhães, C. S. [UNESP]
dc.contributor.authorFerreira, J. C.O.A.
dc.contributor.authorBarbosa, C. M.
dc.contributor.authorGomes, F. H.
dc.contributor.authorBonfá, E.
dc.contributor.authorSilva, C. A.
dc.identifier.citationLupus, v. 26, n. 5, p. 484-489, 2017.
dc.description.abstractObjectives Anti-ribosomal P protein (anti-P) autoantibodies are highly specific for systemic lupus erythematosus (SLE). However, the evaluation of this autoantibody in childhood-onset SLE (cSLE) populations has been limited to a few small series, hampering the interpretation of the clinical and laboratorial associations. Therefore, the objective of this multicenter cohort study was to evaluate demographic, clinical/laboratorial features, and disease damage score in cSLE patients with and without the presence of anti-P antibody. Methods This was a retrospective multicenter study performed in 10 pediatric rheumatology services of São Paulo state, Brazil. Anti-P antibodies were measured by ELISA in 228 cSLE patients. Results Anti-P antibodies were observed in 61/228 (27%) cSLE patients. Frequencies of cumulative lymphadenopathy (29% vs. 15%, p = 0.014), acute confusional state (13% vs. 5%, p = 0.041), mood disorder (18% vs. 8%, p = 0.041), autoimmune hemolytic anemia (34% vs. 15%, p = 0.001), as well as presence of anti-Sm (67% vs. 40%, p = 0.001), anti-RNP (39% vs. 21%, p = 0.012) and anti-Ro/SSA antibodies (43% vs. 25%, p = 0.016) were significantly higher in cSLE patients with anti-P antibodies compared to those without these autoantibodies. A multiple regression model revealed that anti-P antibodies were associated with autoimmune hemolytic anemia (odds ratio (OR) = 2.758, 95% confidence interval (CI): 1.304-5.833, p = 0.008) and anti-Sm antibody (OR = 2.719, 95% CI: 1.365-5.418, p = 0.004). The SLICC/ACR damage index was comparable in patients with and without anti-P antibodies (p = 0.780). Conclusions The novel association of anti-P antibodies and autoimmune hemolytic anemia was evidenced in cSLE patients and further studies are necessary to determine if anti-P titers may vary with this hematological manifestation.en
dc.subjectanti- ribosomal P protein antibodies
dc.subjectautoimmune hemolytic anemia
dc.subjectneuropsychiatric lupus
dc.subjectSystemic lupus erythematosus
dc.titleAnti-ribosomal P antibody: A multicenter study in childhood-onset systemic lupus erythematosus patientsen
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionHospital Darcy Vargas
dc.description.affiliationPediatric Rheumatology Unit Children's Institute Faculdade de Medicina da Universidade de São Paulo (FMUSP)
dc.description.affiliationDivision of Rheumatology Faculdade de Medicina da Universidade de São Paulo (FMUSP)
dc.description.affiliationPediatric Rheumatology Unit State University of Campinas (UNICAMP)
dc.description.affiliationPediatric Rheumatology Unit Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationPediatric Rheumatology Division São Paulo State University (UNESP) Faculdade de Medicina de Botucatu
dc.description.affiliationPediatric Rheumatology Unit Hospital Darcy Vargas
dc.description.affiliationPediatric Rheumatology Unit Ribeirão Preto Medical School FMUSP
dc.description.affiliationUnespPediatric Rheumatology Division São Paulo State University (UNESP) Faculdade de Medicina de Botucatu
dc.rights.accessRightsAcesso aberto
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