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dc.contributor.authorLuchini, Ana Carolina [UNESP]
dc.contributor.authorCosta de Oliveira, Deborah Mara [UNESP]
dc.contributor.authorPellizzon, Claudia Helena [UNESP]
dc.contributor.authorDi Stasi, Luiz Claudio [UNESP]
dc.contributor.authorGomes, Jose Carlos [UNESP]
dc.date.accessioned2014-05-20T13:49:11Z
dc.date.available2014-05-20T13:49:11Z
dc.date.issued2009-01-01
dc.identifierhttp://dx.doi.org/10.1155/2009/432493
dc.identifier.citationMediators of Inflammation. New York: Hindawi Publishing Corporation, p. 7, 2009.
dc.identifier.issn0962-9351
dc.identifier.urihttp://hdl.handle.net/11449/17510
dc.description.abstractThe present study aimed to clarify the role of mast cells in colitis with relapse induced in Wistar rats by trinitrobenzenosulphonic acid. Colitis induction increased the histamine concentration in the colon, which peaked on day 26. The number of mast cells, probably immature, was ten times higher on day 8. Different from animals infected with intestinal parasites, after colitis remission, mast cells do not migrate to the spleen, showing that mast cell proliferation presents different characteristics depending on the inflammation stimuli. Treatment with sulfasalazine, doxantrazole, quercetin, or nedocromil did not increase the histamine concentration or the mast cell number in the colon on day 26, thereby showing absence of degranulation of these cells. In conclusion, although mast cell proliferation is associated with colitis, these cells and their mediators appear to play no clear role in the colitis with relapses. Copyright (C) 2009 Ana Carolina Luchini et al.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent7
dc.language.isoeng
dc.publisherHindawi Publishing Corporation
dc.relation.ispartofMediators of Inflammation
dc.sourceWeb of Science
dc.titleRelationship between Mast Cells and the Colitis with Relapse Induced by Trinitrobenzesulphonic Acid in Wistar Ratsen
dc.typeArtigo
dcterms.licensehttp://www.hindawi.com/journals/apm/apc/
dcterms.rightsHolderHindawi Publishing Corporation
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUNESP, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Pharmacol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil
dc.identifier.doi10.1155/2009/432493
dc.identifier.wosWOS:000266378000001
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
dc.identifier.fileWOS000266378000001.pdf
dc.identifier.lattes0019393779801069
dc.identifier.lattes1697547325096457
unesp.author.lattes0019393779801069
unesp.author.lattes1697547325096457
dc.relation.ispartofjcr3.549
dc.relation.ispartofsjr1,370
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