Show simple item record

dc.contributor.authorVoltan, Aline R.
dc.contributor.authorAlarcon, Kaila M. [UNESP]
dc.contributor.authorFusco-Almeida, Ana M. [UNESP]
dc.contributor.authorSoares, Christiane P. [UNESP]
dc.contributor.authorMendes-Giannini, Maria J.S. [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.date.accessioned2018-12-11T17:14:32Z
dc.date.available2018-12-11T17:14:32Z
dc.date.issued2017-06-01
dc.identifierhttp://dx.doi.org/10.2174/0929867324666170214111205
dc.identifier.citationCurrent Medicinal Chemistry, v. 24, n. 18, p. 1909-1929, 2017.
dc.identifier.issn1875-533X
dc.identifier.issn0929-8673
dc.identifier.urihttp://hdl.handle.net/11449/175139
dc.description.abstractThe focus of this review is the cellular internalisation mechanism of nanostructured systems (NSs) and their endosomal escape for targeted drug delivery. Endocytosis is a cellular process of internalisation of different molecules and foreign microorganisms. It is currently being studied for drug delivery through nanostructured systems. The most commonly studied routes of cellular uptake are phagocytosis, macro-pinocytosis, clathrin-mediated endocytosis, caveolin-mediated endocytosis, and clathrin and caveolin-independent endocytosis. The mechanism utilised by NSs for cellular entry depends on factors such as cell type and its physicochemical properties. Currently, with the development of drugs-loaded onto NSs, it has been possible to increase the therapeutic index against few diseases. The NSs can deliver the active drug at locations that conventional drugs cannot, thereby minimising unwanted side effects. On cellular entry of NSs, there is a possibility of an endosomal escape of the contents into the cytoplasm, a mechanism that can be exploited so that NSs can migrate intra-cellularly and deliver the drug to the target of interest. Designing endolysosomal escape strategy is not an easy task, but it is critical for the optimal pharmacological action on the target tissue. The cellular uptake of drugs is a very important factor in therapy. Although NSs have emerged as effective drug delivery vehicle for treatment of diseases, it is crucial to understand the mechanism of NSs endocytosis.en
dc.format.extent1909-1929
dc.language.isoeng
dc.relation.ispartofCurrent Medicinal Chemistry
dc.sourceScopus
dc.subjectDrug delivery
dc.subjectEndocytosis
dc.subjectEscape pathway endolysosomal
dc.subjectNanostructured systems
dc.subjectPhagocytosis
dc.titleHighlights in endocytosis of nanostructured systemsen
dc.typeResenha
dc.contributor.institutionUniv Federal de Goiás - UFG
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Biochemistry and Molecular Biology Institute of Biological Sciences II (ICB II) Univ Federal de Goiás - UFG, Avenida Esperança, Campus Samambaia
dc.description.affiliationDepartment of Drugs and Medicines School of Pharmaceutical Sciences Univ Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, Campus
dc.description.affiliationDepartment of Clinical Analysis School of Pharmaceutical Sciences Univ Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, Campus
dc.description.affiliationUnespDepartment of Drugs and Medicines School of Pharmaceutical Sciences Univ Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, Campus
dc.description.affiliationUnespDepartment of Clinical Analysis School of Pharmaceutical Sciences Univ Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, Campus
dc.identifier.doi10.2174/0929867324666170214111205
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-85028915578
dc.relation.ispartofsjr1,015
Localize o texto completo

Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record