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dc.contributor.authorDomingo Francia-Farje, Luis Alberto
dc.contributor.authorSilva, Denise Salioni [UNESP]
dc.contributor.authorVolpato, Gustavo Tadeu
dc.contributor.authorAlves Fernandes, Glaura Scantamburlo
dc.contributor.authorCarnietto, Nilson [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorKempinas, Wilma de Grava [UNESP]
dc.identifier.citationJournal of Toxicology and Environmental Health-part A-current Issues. Philadelphia: Taylor & Francis Inc, v. 73, n. 13-14, p. 985-990, 2010.
dc.description.abstractIt is well established that sibutramine produces weight loss and is used frequently in women of childbearing age. However, the potential adverse consequences attributed to sibutramine use by women who may become pregnant is not known. It was thus of interest to determine the effects of sibutramine on the reproductive performance of pregnant rats. Overweight as well as non-overweight female Wistar rats were treated with sibutramine (6 mg/kg) orally, daily for 15 d and then mated with normal male rats. Pregnancy was confirmed and treatment continued with sibutramine until d 14 of pregnancy. on d 20 of pregnancy all rats were anesthetized for determination of various maternal and fetal parameters. There was a significant maternal weight reduction at the end of pregnancy in the non-overweight drug-treated group compared to the control (non-overweight, no drug). Sibutramine alone and overweight condition alone produced a significant increase in postimplantation loss and placental index. In the overweight with or without sibutramine groups a significant decrease in fetal weight was noted. Data suggest that sibutramine alone or the condition of excess weight in the absence of drugs produced impaired reproductive performance. However, treatment of overweight rats with sibutramine did not further exacerbate fetal loss compared to sibutramine alone or the effects noted with excess weight alone.en
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Toxicology and Environmental Health: Part A Current Issues
dc.sourceWeb of Science
dc.titleSibutramine Effects on the Reproductive Performance of Pregnant Overweight and Non-Overweight ratsen
dcterms.rightsHolderTaylor & Francis Inc
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Morfol, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Postgrad Program Cellular & Struct Biol, São Paulo, Brazil
dc.description.affiliationUniv Fed Mato Grosso, Inst Biol & Hlth Sci, Belo Horizonte, MG, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, Sch Med, Dept Clin Med, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias Botucatu, Dept Morfol, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Sch Med, Dept Clin Med, São Paulo, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
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