American tegumentary leishmaniasis: severe side effects of pentavalent antimonial in a patient with chronic renal failure
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Data
2019-05-01
Autores
Marques, Silvio Alencar [UNESP]
Merlotto, Maira Renata [UNESP]
Ramos, Paulo Muller [UNESP]
Alencar Marques, Mariangela Esther [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Soc Brasileira Dermatologia
Resumo
Pentavalent antimonials are the first-line drug treatment for American tegumentary leishmaniasis. We report on a patient with chronic renal failure on hemodialysis who presented with cutaneous lesions of leishmaniasis for four months. The patient was treated with intravenous meglumine under strict nephrological surveillance, but cardiotoxicity, acute pancreatitis, pancytopenia, and cardiogenic shock developed rapidly. Deficient renal clearance of meglumine antimoniate can result in severe toxicity, as observed in this case. These side effects are related to cumulative plasma levels of the drug. Therefore, second-line drugs like amphotericin B are a better choice for patients on dialysis.
Descrição
Palavras-chave
Amphotericin B, Kidney failure, chronic, Leishmaniasis, cutaneous, Meglumine, Pancreatitis, Renal insufficiency, Skin ulcer
Como citar
Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 94, n. 3, p. 355-357, 2019.