Geraniol and linalool anticandidal activity, genotoxic potential and embryotoxic effect on zebrafish
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Data
2018-11-01
Autores
Singulani, Junya L. [UNESP]
Pedroso, Reginaldo S.
Ribeiro, Arthur B.
Nicolella, Heloiza D.
Freitas, Karoline S.
Damasceno, Jacqueline L.
Vieira, Tatiana M.
Crotti, Antonio E. M.
Tavares, Denise C.
Martins, Carlos H. G.
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Editor
Future Medicine Ltd
Resumo
Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants. Materials & methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model. Results: Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800g/ml and the linalool at concentration of 125g/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3g/ml, respectively. Conclusion: Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations. [GRAPHICS] .
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antifungal, cytotoxicity, embryotoxicity, geraniol, linalool
Como citar
Future Microbiology. London: Future Medicine Ltd, v. 13, n. 15, p. 1637-1646, 2018.