Extensive pyoderma gangrenosum-like lesions revealing a case of hyperzincemia and hypercalprotectinemia: when to suspect it?
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Data
2019-11-01
Autores
Resende, Ludimila Oliveira [UNESP]
Scotton Jorge, Marilia Formentini [UNESP]
Schmitt, Juliano Vilaverde [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Soc Brasileira Dermatologia
Resumo
Hyperzincemia and hypercalprotectinemia is a rare inflammatory disease caused by a mutation in the PSTPIP1 gene, with a dysregulation of calprotectin metabolism. Calprotectin is a zinc-binding protein with antimicrobial properties and pro-inflammatory action. The authors report the case of a 20 year-old girl with cutaneous ulcers comparable with pyoderma gangrenosum, growth failure and chronic anemia, who was given the diagnosis of hyperzincemia and hypercalprotectinemia. Measurement of serum zinc and calprotectin concentrations are indicated in these cases. (C) 2019 Sociedade Brasileira de Dermatologia. Published by Elsevier Espana, S.L.U.
Descrição
Palavras-chave
Arthritis, Inflammation, Skin manifestations, Zinc
Como citar
Anais Brasileiros De Dermatologia. Rio De Janeiro Rj: Soc Brasileira Dermatologia, v. 94, n. 6, p. 713-716, 2019.