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dc.contributor.authorSoares, R. M.
dc.contributor.authorCortez, A.
dc.contributor.authorHeinemann, M. B.
dc.contributor.authorSakamoto, S. M.
dc.contributor.authorMartins, V. G.
dc.contributor.authorBacci, M.
dc.contributor.authorFernandes, FMD
dc.contributor.authorRichtzenhain, L. J.
dc.identifier.citationJournal of General Virology. Reading: Soc General Microbiology, v. 84, p. 1505-1515, 2003.
dc.description.abstractThe 3'-terminal 853 nt (and the putative 283 aa) sequence of the VP2-encoding gene from 29 field strains of porcine parvovirus (PPV) were determined and compared both to each other and with other published sequences. Sequences were examined using maximum-parsimony and statistical analyses for nucleotide diversity and sequence variability. Among the nucleotide sequences of the PPV field strains, 26 polymorphic sites were encountered; 22 polymorphic sites were detected in the putative amino acid sequence. Mapping polymorphic sites of protein data onto the three-dimensional (3D) structure of PPV VP2 revealed that almost all substitutions were located on the external surface of the viral capsid. Mapping amino acid substitutions to the alignment between PPV VP2 sequences and the 3D structure of canine parvovirus (CPV) capsid, many PPV substitutions were observed to map to regions of recognized antigenicity and/or to contain phenotypically important residues for CPV and other parvoviruses. In spite of the high sequence similarity, genetic analysis has shown the existence of at least two virus lineages among the samples. In conclusion, these results highlight the need for close surveillance on PPV genetic drift, with an assessment of its potential ability to modify the antigenic make-up of the virus.en
dc.publisherSoc General Microbiology
dc.relation.ispartofJournal of General Virology
dc.sourceWeb of Science
dc.titleGenetic variability of porcine parvovirus isolates revealed by analysis of partial sequences of the structural coding gene VP2en
dcterms.rightsHolderSoc General Microbiology
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecn, Dept Med Vet Prevent & Saúde Anim, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Brasilia, Fac Agron & Med Vet, Brasilia, DF, Brazil
dc.description.affiliationUniv Fed São Paulo, Inst Ciências Biomed, Dept Microbiol Imunol & Parasitol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Bioquim, Ctr Estudos Insetos Sociais, Rio Claro, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biociencias, Lab Ictiogenet, BR-05508 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Bioquim, Ctr Estudos Insetos Sociais, Rio Claro, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Rio Claropt[6]
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