Reação inflamatória no sistema nervoso central de cães com leishmaniose visceral e pesquisa de amastigotas e linfócitos T na medula espinhal
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Data
2023-02-07
Autores
Pellissari, Maria Cecilia Clarindo
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Universidade Estadual Paulista (Unesp)
Resumo
O sistema nervoso central é composto por encéfalo e medula espinhal, ao passo que gânglios nervosos e nervos constituem o sistema nervoso periférico. Lesões inflamatórias na medula espinhal relacionadas à Leishmaniose Visceral são pouco descritas na literatura humanos ou animais. O presente estudo tem como objetivo caracterizar a distribuição e intensidade da inflamação encefálica e medular de cães naturalmente infectados por Leishmania infantum. Além disso, verificar a presença e distribuição de linfócitos TCD3 e investigar possíveis vias de migração destas células na medula espinhal de cães acometidos por Leishmaniose Visceral. Para tanto, foi realizada uma revisão bibliográfica consultando plataformas de bases de dados como PubMed, LILACS, SciELO, Google Scholar e Portal de Periódicos CAPES, com ênfase em artigos publicados entre os anos de 2000 a 2022, que abordavam as alterações neurológicas relacionadas à Leishmaniose, além de outros protozoários, afim de explanar as funções fisiológicas e patológicas das barreiras pertencentes ao sistema nervoso central e periférico, e as possíveis vias de migração leucocitária e entrada de agentes infecciosos no sistema nervoso.
The central nervous system is composed of the encephalon and spinal cord, whereas nerve ganglia and nerves constitute the peripheral nervous system. Inflammatory lesions in the spinal cord related to Visceral Leishmaniasis are poorly described in human or animal literature. The present study aims to characterize the distribution and intensity of brain and spinal cord inflammation in dogs naturally infected with Leishmania infantum. In addition, to verify the presence and distribution of TCD3 lymphocytes and investigate possible migration pathways of these cells in the spinal cord of dogs affected by Visceral Leishmaniasis. To this end, a literature review was carried out consulting database platforms such as PubMed, LILACS, SciELO, Google Scholar and CAPES Periodical Portal, with emphasis on articles published between the years 2000 and 2022, which addressed the neurological changes related to Leishmaniasis, as well as other protozoa, in order to explain the physiological and pathological functions of the barriers belonging to the central and peripheral nervous system, and the possible routes of leukocyte migration and entry of infectious agents into the nervous system.
The central nervous system is composed of the encephalon and spinal cord, whereas nerve ganglia and nerves constitute the peripheral nervous system. Inflammatory lesions in the spinal cord related to Visceral Leishmaniasis are poorly described in human or animal literature. The present study aims to characterize the distribution and intensity of brain and spinal cord inflammation in dogs naturally infected with Leishmania infantum. In addition, to verify the presence and distribution of TCD3 lymphocytes and investigate possible migration pathways of these cells in the spinal cord of dogs affected by Visceral Leishmaniasis. To this end, a literature review was carried out consulting database platforms such as PubMed, LILACS, SciELO, Google Scholar and CAPES Periodical Portal, with emphasis on articles published between the years 2000 and 2022, which addressed the neurological changes related to Leishmaniasis, as well as other protozoa, in order to explain the physiological and pathological functions of the barriers belonging to the central and peripheral nervous system, and the possible routes of leukocyte migration and entry of infectious agents into the nervous system.
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Palavras-chave
Leishmania, Mielite, Encefalite, Linfócito T, Myelitis, Encephalitis, T lymphocytes