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dc.contributor.authorDias, M. B.
dc.contributor.authorNucci, T. B.
dc.contributor.authorBranco, L. G. S.
dc.contributor.authorGargaglioni, L. H. [UNESP]
dc.identifier.citationActa Physiologica. Malden: Wiley-blackwell, v. 204, n. 3, p. 435-442, 2012.
dc.description.abstractAim: It has been suggested that the medullary raphe (MR) plays a key role in the physiological responses to hypoxia. As opioid mu-receptors have been found in the MR, we studied the putative role of opioid mu-receptors in the rostral MR (rMR) region on ventilation in normal and 7% hypoxic conditions.Methods: We measured pulmonary ventilation ((V) over dotE) and the body temperatures (Tb) of male Wistar rats before and after the selective opioid l-receptor antagonist CTAP ( d-Phe-Cys-Tyr-d-Trp-Arg-Thr-Pen-Thr-NH2, cyclic, 0.1 mu g per 0.1 mu L) was microinjected into the rMR during normoxia or after 60 min of hypoxia.Results: The animals treated with intra-rMR CTAP exhibited an attenuation of the ventilatory response to hypoxia ( 430 +/- 86 mL kg) 1 min) 1) compared with the control group ( 790 +/- 82 mL kg) 1 min) 1) ( P < 0.05). No differences in the Tb were observed between groups during hypoxia.Conclusion: These data suggest that opioids acting on l-receptors in the rMR exert an excitatory modulation of hyperventilation induced by hypoxia.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipINCT-Fisiologia Comparada
dc.description.sponsorshipPrograma de Apoio aos Núcleos de Excelência (PRONEX)
dc.relation.ispartofActa Physiologica
dc.sourceWeb of Science
dc.subjectControl of breathingen
dc.subjectPulmonary ventilationen
dc.subjectraphe nucleien
dc.titleOpioid mu-receptors in the rostral medullary raphe modulate hypoxia-induced hyperpnea in unanesthetized ratsen
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Physiol Sci, Goiania, Go, Brazil
dc.description.affiliationUniv São Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, BR-05508 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ FCAV Jaboticabal, Dept Anim Morphol & Physiol, São Paulo, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ FCAV Jaboticabal, Dept Anim Morphol & Physiol, São Paulo, SP, Brazil
dc.rights.accessRightsAcesso restrito
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
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