Anxiolytic effects of erythrinian alkaloids from Erythrina mulungu
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Data
2007-01-01
Autores
Flausino, Otavio
Santos, Luciana de Avila
Verli, Hugo
Pereira, Ana Maria
Bolzani, Vanderlan da Silva [UNESP]
Nunes-de-Souza, Ricardo Luiz
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Amer Chemical Soc
Resumo
One new erythrinian alkaloid derivative, (+)-11 alpha-hydroxyerythravine (1), and the known (+)-erythravine (2) and (+)-alpha-hydroxyerysotrine (3) were isolated from the flowers of Erythrina mulungu. Their structures were determined by spectroscopic/spectrometric data interpretation of H-1, C-13, and 2D NMR and MS experiments. The relative configuration was established by NOESY analysis, while the conformation adopted by these molecules was evaluated through molecular modeling studies and coupling constants obtained by NMR analysis. Furthermore, the anxiolytic effects of the E. mulungu aqueous alcoholic crude extract and of the purified alkaloids were evaluated using the elevated T-maze test.
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Journal of Natural Products. Washington: Amer Chemical Soc, v. 70, n. 1, p. 48-53, 2007.