Synthesis, characterization and initial biological studies of a new platinum(II) complex with deoxyalliin
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Data
2006-07-10
Autores
Corbi, Pedro P.
Massabni, Antonio Carlos [UNESP]
Costa-Neto, Claudio M.
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Editor
Taylor & Francis Ltd
Resumo
A new platinum(II) complex with deoxyalliin was synthesized and characterized by chemical and spectroscopic techniques. Elemental and mass spectrometry analyses of the solid complex fit to the composition [Pt(C6H11NO2S)Cl-2] center dot H2O. C-13 NMR, N-15 NMR and infrared spectra of the complex are consistent with coordination of deoxyalliin to Pt( II) through the nitrogen and sulfur atoms forming a square-planar geometry. The complex is soluble in dimethylsulfoxide. Biological analysis for evaluation of a potential cytotoxic effect of the complex was performed using HeLa cells, a human cervix adenocarcinoma-derived cell line. The results were compared with those of a palladium( II) complex previously described.
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platinum(II), deoxyalliin, N-15 NMR, cancer therapy
Como citar
Journal of Coordination Chemistry. Abingdon: Taylor & Francis Ltd, v. 59, n. 10, p. 1101-1106, 2006.