Immunohistochemical aspects of basal cell adenoma and canalicular adenoma of salivary glands
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Data
2001-05-12
Autores
Machado de Sousa, S. O.
Soares de Araújo, N.
Corrêa, L.
Soubhia, Ana Maria Pires [UNESP]
Cavalcanti de Araújo, V.
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Resumo
Basal cell adenoma is a benign epithelial neoplasm with a uniform histologic appearance dominated by basaloid cells. Those cells may be distributed in various arrangements as solid, trabecular, tubular and membranous. Canalicular adenoma is also a benign neoplasm composed by columnar cells arranged in branching and interconnecting cords of single or double cell thick rows. There is some disagreement among investigators about whether canalicular adenoma should be included within the basal cell adenoma histologic spectrum. In the present study we compared the expression of cytokeratins (CK), vimentin and muscle-specific actin, utilizing immunohistochemical technique, in three cases diagnosed as basal cell adenomas predominantly of the solid type, and three cases of canalicular adenomas. The results obtained showed a distinct immunoprofile for both neoplasms. Solid areas of basal cell adenomas did not stain for any of the tested antibodies; only when there was tubular differentiation, those structures expressed CKs 7, 8, 14, and 19 in luminal cells and vimentin in non-luminal cells. On the other hand, canalicular adenomas strongly expressed CKs 7 and 13. The panel of antibodies utilized supports the separation of the two entities. © 2001 Elsevier Science Ltd.
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Palavras-chave
Basal cell adenoma, Canalicular adenoma, Immunohistochemistry, Salivary gland tumours, alpha actin, cytokeratin, cytokeratin 14, cytokeratin 19, cytokeratin 7, cytokeratin 8, protein antibody, unclassified drug, vimentin, adenoma, basal cell, benign tumor, cancer diagnosis, controlled study, diagnostic accuracy, diagnostic value, differential diagnosis, histopathology, human, human tissue, immunohistochemistry, lacrimal duct, priority journal, protein expression, salivary gland tumor, Actins, Adenocarcinoma, Adenoma, Humans, Keratin-7, Keratins, Neoplasm Proteins, Salivary Gland Neoplasms, Vimentin
Como citar
Oral Oncology, v. 37, n. 4, p. 365-368, 2001.