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dc.contributor.authorHonorato de Oliveira, Georgino [UNESP]
dc.contributor.authorMoreira, Vanessa [UNESP]
dc.contributor.authorRibeiro Goes, Sheila Patricia [UNESP]
dc.date.accessioned2014-05-27T11:20:35Z
dc.date.available2014-05-27T11:20:35Z
dc.date.issued2002-12-15
dc.identifierhttp://dx.doi.org/10.1016/S0378-4274(02)00295-3
dc.identifier.citationToxicology Letters, v. 136, n. 2, p. 143-150, 2002.
dc.identifier.issn0378-4274
dc.identifier.urihttp://hdl.handle.net/11449/67147
dc.description.abstractMeasurements of plasma cholinesterase (pl.ChE), brain cholinesterase (Br.ChE) and brain Neuropathy Target Esterase (Br.NTE) were made in three different lineages of chickens. All birds received toxicants through gavage in a single oral dose between 08:00 and 09:00 h, after overnight fast. Babcock chickens were treated with 800 mg/kg tri-ortho-cresyl phosphate (TOCP) or 80 mg/kg trichlorfon. The TOCP group had 82% Br.NTE inhibition, when compared to the control group, and no birds displayed symptoms of clinical organophosphate-induced delayed neuropathy (OPIDN). Hy-line w36 lineage chickens were given 1600 mg/kg TOCP and despite this higher dose, Br.NTE inhibition was similar that presented by Babcock chickens. Isabrown chickens were given 1600 mg/kg TOCP or 80 mg/kg trichlorfon. At 36 h all trichlorfon treated birds had from 80 to 90% inhibition of Pl.ChE and Br.ChE, when compared to controls. However, Br.NTE was inhibited less than 20%, and there were no clinical signs of OPIDN. All TOCP treated isabrown chickens had more than 80% Br.NTE inhibition while one of them exhibited just light signs of OPIDN, two chickens became totally paralyzed. This finding suggested that chicken strain was important in the appearance of OPIDN. In addition, 70-80% of NTE inhibition was necessary but was not sufficient to produce OPIDN in chickens, since babcock and hy-line w36 chickens exhibited NTE inhibition in the range of 70-80% without clinical signs of OPIDN. © 2002 Elsevier Science Ireland Ltd. All rights reserved.en
dc.format.extent143-150
dc.language.isoeng
dc.relation.ispartofToxicology Letters
dc.sourceScopus
dc.subjectChicken strain
dc.subjectCholinesterase
dc.subjectNeurotoxic target esterase
dc.subjectOrganophosphate induced delayed neuropathy
dc.subjectTri-ortho-cresyl-phosphate
dc.subjectTrichlorfon
dc.subjectcholinesterase
dc.subjectmetrifonate
dc.subjectneurotoxic esterase
dc.subjectorganophosphate
dc.subjecttri ortho cresyl phosphate
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbrain level
dc.subjectchicken
dc.subjectcholinesterase blood level
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectenzyme inhibition
dc.subjectfeeding
dc.subjectgenetic difference
dc.subjectline difference
dc.subjectneuropathy
dc.subjectnonhuman
dc.subjectorganophosphate induced delayed neuropathy
dc.subjectparalysis
dc.subjectpriority journal
dc.subjectsymptom
dc.subjectAnimals
dc.subjectBrain
dc.subjectCarboxylic Ester Hydrolases
dc.subjectCentral Nervous System Diseases
dc.subjectChickens
dc.subjectCholinesterases
dc.subjectInsecticides
dc.subjectTime Factors
dc.subjectTritolyl Phosphates
dc.subjectAves
dc.subjectGallus gallus
dc.titleOrganophosphate induced delayed neuropathy in genetically dissimilar chickens: Studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfonen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.description.affiliationResearch of Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.description.affiliationFaculdade de Ciências Farmaceuticas UNESP, Rod. Araraquara-Jau km 1 Campustact, 14801-902 Araraquara São Paulo
dc.description.affiliationUnespDepartment of Natural Active Principles and Toxicology School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.description.affiliationUnespResearch of Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences UNESP, Araraquara, SP
dc.description.affiliationUnespFaculdade de Ciências Farmaceuticas UNESP, Rod. Araraquara-Jau km 1 Campustact, 14801-902 Araraquara São Paulo
dc.identifier.doi10.1016/S0378-4274(02)00295-3
dc.identifier.wosWOS:000179592400006
dc.rights.accessRightsAcesso restrito
dc.identifier.scopus2-s2.0-0037114474
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.relation.ispartofjcr3.166
dc.relation.ispartofsjr1,103
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