Ativação de macrófagos por produtos naturais obtidos da Achillea millefolium L. (Asteraceae)

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Data

2003-12-01

Autores

Lopes, F. C M [UNESP]
Moreira, Raquel Regina Duarte [UNESP]
Carlos, Iracilda Zeppone [UNESP]

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Resumo

Plants are a valuable source of natural products for the maintenance of human health. The purpose of this paper was the study of immunologic activity of yarrow (Achillea millefolium L.), a largely used plant in popular medicine that has many different properties such as: antiinflammatory, astringent, antiseptic and antispasmodic. Macrophages stimulation was evaluated by the determination of H2O2, NO and TNF-α in supernatants of peritoneal macrophages cultures of mice in the presence of the yarrow leaves extract. The thin layer chromatography of extract was also analyzed, showing rutin. All concentrations showed a moderate release of H2O2 and the concentrations of 6, 8 and 10mg/mL had a higher release of NO. The TNF-a was produced in all concentrations, but the best result was obtained at 4mg/mL. Analyzing the results, it is suggested that the yarrow ethanolic extract can modulate the macrophages activation.

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Palavras-chave

Achillea millefolium L., Hydrogen peroxide, Macrophages, Nitric oxide, Tumor necrosis factor- α, Yarrow, Achillea millefolium extract, hydrogen peroxide, natural product, nitric oxide, tumor necrosis factor alpha, Achillea, animal cell, antiinflammatory activity, antispasmodic activity, astringent activity, controlled study, dose response, drug activity, immunoreactivity, macrophage activation, mouse, nonhuman, peritoneum macrophage, plant leaf, supernatant, thin layer chromatography

Como citar

Revista de Ciencias Farmaceuticas, v. 24, n. 1, p. 61-69, 2003.