Determination of flutamide in tablets by high-performance liquid chromatography
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Data
2005-04-01
Autores
Salgado, Hérida Regina Nunes [UNESP]
De Menezes, Manoel [UNESP]
Storti, Madge Patrícia Betto [UNESP]
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Resumo
Flutamide is a potent antiandrogen used for the treatment of prostatic cancer. A simple, sensitive and accurate high-performance liquid Chromatographic (HPLC) method is presented for quantitative determination of flutamide in tablets, using a reversed-phase technique and UV detection at 240 nm. The isocratic elution was used to quantify the analyte. The samples were chromatographed on Luna-C18 column and the mobile phase was 0.05 M phosphate buffer pH 4.0 - acetonitrile (50:50, v/v). The method was linear between 2.9 - 11.6 mg L -1. Over the tested concentration range the intra-day relative standard deviation for replicate analysis in tablets ranged from 0.44 to 0.78%. It was also found that the excipients in the commercial tablets did not interfere with the method.
Descrição
Palavras-chave
Analysis in tablets, Flutamide, High-performance liquid chromatography (HPLC), Pharmaceutical analysis, acetonitrile, flutamide, drug determination, high performance liquid chromatography, prostate cancer, reversed phase high performance liquid chromatography, tablet
Como citar
Acta Farmaceutica Bonaerense, v. 24, n. 2, p. 246-249, 2005.