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dc.contributor.authorRochel-Maia, Sabrina S.
dc.contributor.authorSantos, Fernanda C. A. [UNESP]
dc.contributor.authorVilamaior, Patrícia S. L. [UNESP]
dc.contributor.authorJustulin Jr., Luis A.
dc.contributor.authorFelisbino, Sérgio L. [UNESP]
dc.contributor.authorGóes, Rejane M. [UNESP]
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.date.accessioned2014-05-27T11:26:06Z
dc.date.available2014-05-27T11:26:06Z
dc.date.issued2011-11-01
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21938680
dc.identifier.citationHistology and Histopathology, v. 26, n. 11, p. 1423-1434, 2011.
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/11449/72784
dc.description.abstractTIMPs in the prostates of male and female gerbils and evaluated the effects of testosterone on the expression of these enzymes. Ventral prostates from male gerbils that were either intact or had been castrated for 7 or 21 days, along with prostates from female gerbils that were either intact or had been treated with testosterone for 7 or 21 days, were submitted to histological, stereological and immunohistochemical analyses. Stereology of prostatic components showed significant alterations of tissue compartments in the ventral male prostate after castration, especially after 21 days, with a significant increase in stroma. Administration of testosterone led to disorganization in the female prostate, with a significant increase in collagen fibers and smooth muscle cells after 21 days, along with the development of epithelial lesions such as PINs. MMP-2 increased after 21 days of castration in males; however, the TIMP-2 immunoreaction for this group was weak or absent. In females, the expression of MMP-2 appeared to decrease after 7 days of treatment with testosterone, but after 21 days, both epithelium and stroma showed a stronger reaction for MMP-2 than the controls. The expression of TIMP-2 in the treated females was similar to its expression in the castrated males. We conclude that the distribution of MMPs and TIMPs in both male and female prostates is altered by androgen manipulation, but the mechanism of stromal regulation appears to be distinct between genders because both the lack of T in castrated males and the excess levels of T in treated females lead to the same effect.en
dc.format.extent1423-1434
dc.language.isoeng
dc.relation.ispartofHistology and Histopathology
dc.sourceScopus
dc.subjectFemale prostate
dc.subjectMMP
dc.subjectTestosterone
dc.subjectTIMP
dc.subjectVentral prostate
dc.subjectandrogen
dc.subjectgelatinase A
dc.subjecttestosterone
dc.subjecttissue inhibitor of metalloproteinase 2
dc.subjectanimal
dc.subjectdrug effect
dc.subjectenzymology
dc.subjectfemale
dc.subjectgerbil
dc.subjectimmunohistochemistry
dc.subjectmale
dc.subjectmetabolism
dc.subjectorchiectomy
dc.subjectprostate
dc.subjectsexual development
dc.subjectAndrogens
dc.subjectAnimals
dc.subjectFemale
dc.subjectGerbillinae
dc.subjectImmunohistochemistry
dc.subjectMale
dc.subjectMatrix Metalloproteinase 2
dc.subjectOrchiectomy
dc.subjectProstate
dc.subjectSex Characteristics
dc.subjectTissue Inhibitor of Metalloproteinase-2
dc.subjectMeriones unguiculatus
dc.titleMMP-2 and TIMP-2 in the prostates of male and female mongolian gerbils: Effects of hormonal manipulationen
dc.typeArtigo
dcterms.licensehttp://revistas.um.es/analesps/about/submissions#copyrightNotice
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro (UFTM)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationDepartment of Cell Biology Institute of Biology State University of Campinas (UNICAMP), São Paulo
dc.description.affiliationDepartment of Morphology Institute of Biology Sciences Federal University of Goiás (UFG), Goiás
dc.description.affiliationDepartment of Morphology Federal University of Triângulo Mineiro-UFTM, Uberaba, Minas Gerais
dc.description.affiliationDepartment of Morphology-Institute of Biosciences (IBB) São Paulo State University (UNESP), São Paulo
dc.description.affiliationDepartment of Biology Institute of Biosciences, Humanities, and Exact Sciences (IBILCE) São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespDepartment of Morphology-Institute of Biosciences (IBB) São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespDepartment of Biology Institute of Biosciences, Humanities, and Exact Sciences (IBILCE) São Paulo State University (UNESP), São Paulo
dc.rights.accessRightsAcesso aberto
dc.identifier.scopus2-s2.0-80053181072
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
dc.identifier.file2-s2.0-80053181072.pdf
dc.identifier.lattes7066358123790434
dc.identifier.orcid0000-0002-0970-4288
dc.identifier.orcid0000-0001-9559-5497
unesp.author.lattes7066358123790434[3]
unesp.author.orcid0000-0001-9559-5497[3]
unesp.author.orcid0000-0002-0970-4288[7]
dc.relation.ispartofjcr2.015
dc.relation.ispartofsjr0,672
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