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dc.contributor.authorBego, Amadeu Moura [UNESP]
dc.contributor.authorFrem, Regina Célia Galvão [UNESP]
dc.contributor.authorNetto, Adelino Vieira de Godoy [UNESP]
dc.contributor.authorMauro, Antonio Eduardo [UNESP]
dc.contributor.authorAnanias, Sandra R. [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.authorda Rocha, Michelle C. [UNESP]
dc.date.accessioned2014-05-20T13:23:58Z
dc.date.available2014-05-20T13:23:58Z
dc.date.issued2009-01-01
dc.identifierhttp://dx.doi.org/10.1590/S0103-50532009000300005
dc.identifier.citationJournal of The Brazilian Chemical Society. São Paulo: Soc Brasileira Quimica, v. 20, n. 3, p. 437-444, 2009.
dc.identifier.issn0103-5053
dc.identifier.urihttp://hdl.handle.net/11449/7335
dc.description.abstractThe 1,2,4-triazolyl-bridged polynuclear complexes [{PdCl(2)(mu-Htrz)}(n)] (1) and [{PdBr(2)(mu-Htrz)}(n)] (2) have been obtained in this work. Compound 1 is prepared by the displacement of acetonitrile from [PdCl(2)(MeCN)(2)] by 1,2,4-triazole (Htrz). Further addition of potassium bromide to the reaction medium afforded complex 2. The new complexes have been isolated, purified and characterized by means of elemental analysis, IR and UV-visible electronic spectroscopies and thermogravimetric (TG) curves. The experimental data suggested that, in both cases, the coordination of 1,2,4-Htrz takes place through the N(2) and N(4) atoms, bridging the palladium centers. The square-planar coordination polyhedron of palladium(II) is determined by two nitrogen atoms from the triazole ligands, while the other two coordination positions are occupied by the chloro (1) or bromo (2) ligands. TG curves indicated that the nature of the anionic ligand does not affect significantly the thermal stability of 1 and 2. The final products of the thermal decompositions were identified as metallic palladium by X-ray powder diffractometry. Preliminary tests involving the evaluation of the effects of compounds 1, 2 and Htrz on H(2)O(2) and NO production in cultures of peritoneal macrophages from BALB/c mice were carried out in vitro.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent437-444
dc.language.isoeng
dc.publisherSoc Brasileira Quimica
dc.relation.ispartofJournal of the Brazilian Chemical Society
dc.sourceWeb of Science
dc.subjectpalladium(II) complexesen
dc.subject1,2,4-triazoleen
dc.subjectmacrophagesen
dc.subjectnitric oxideen
dc.subjecthydrogen peroxideen
dc.titleImmunomodulatory Effects of Palladium(II) Complexes of 1,2,4-Triazole on Murine Peritoneal Macrophagesen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Quimica
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.description.affiliationUniv Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim Araraquara, Dept Quim Geral & Inorgan, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.identifier.doi10.1590/S0103-50532009000300005
dc.identifier.scieloS0103-50532009000300005
dc.identifier.wosWOS:000266403300004
dc.rights.accessRightsAcesso aberto
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
dc.identifier.lattes3300223970814448
dc.identifier.lattes7927677053650819
dc.identifier.orcid0000-0002-0057-7964
unesp.author.lattes3300223970814448
unesp.author.lattes7927677053650819[3]
unesp.author.orcid0000-0002-0057-7964[3]
dc.relation.ispartofjcr1.444
dc.relation.ispartofsjr0,357
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