The action of aminoguanidine on the liver of trained diabetic rats
Carregando...
Arquivos
Data
2013-07-09
Autores
e Nico, Edmara Tereza Meira [UNESP]
de Oliveira, Patrícia Rosa [UNESP]
de Souza, Leonardo Peres [UNESP]
Pereira, Franco Dani Campos [UNESP]
Delbin, Maria Andréia [UNESP]
Zanesco, Angelina [UNESP]
Camargo-Mathias, Maria Izabel [UNESP]
Título da Revista
ISSN da Revista
Título de Volume
Editor
Resumo
Background: This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques.Methods: The rats used in this study were divided into five groups: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine.Results: The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels.Conclusion: Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin. © 2013 e Nico et al.; licensee BioMed Central Ltd.
Descrição
Palavras-chave
Aminoguanidine, Diabetes type 1, Liver, Physical exercises, Rats, aminoguanidine, polysaccharide, animal experiment, animal model, animal tissue, cellular distribution, controlled study, cytoplasm, diabetes mellitus, exercise, insulin dependent diabetes mellitus, Kupffer cell, liver, liver blood vessel, liver congestion, liver histology, liver hypertrophy, male, nonhuman, rat
Como citar
Journal of Diabetes and Metabolic Disorders, v. 12, n. 1, 2013.