Detection of HPV in mouth floor squamous cell carcinoma and its correlation with clinicopathologic variables, risk factors and survival

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dc.contributor.authorSimonato, L. E. [UNESP]
dc.contributor.authorGarcia, J. F. [UNESP]
dc.contributor.authorSundefeld, Maria Lúcia Marçal Mazza [UNESP]
dc.contributor.authorMattar, N. J.
dc.contributor.authorVeronese, L. A. [UNESP]
dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionPathol Aracatuba Pathol Inst
dc.date.accessioned2014-05-20T15:33:36Z
dc.date.available2014-05-20T15:33:36Z
dc.date.issued2008-11-01
dc.description.abstractThe human papillomavirus (HPV) has been historically associated with head and neck cancers, although its role in oral carcinogenesis remains poorly defined. The purpose of this study was to investigate the prevalence of HPV in mouth floor squamous cell carcinoma and correlate it with clinicopathologic variables, risk factors and survival. HPV presence was evaluated by nested polymerase chain reaction (nPCR) in 29 paraffin-embedded specimens of mouth floor squamous cell carcinoma. HPV DNA was detected in 17.2% (5 of 29) of the specimens; the highest prevalence was observed in non-smoking patients over the age of 60 years. All HPV DNA positive specimens were detected in men with clinical stage III and IV lesions, being most of which were moderately differentiated. Despite this correlation there were no statistically significant differences observed among the analyzed variables, including patients' survival. The relatively low incidence of HPV DNA present in these tumors suggests that this virus does not, by itself, have a significant role in the development of mouth floor squamous cell carcinoma. J Oral Pathol Med (2008) 37: 593-598en
dc.description.affiliationUniv Estadual Paulista, Sch Dent, Dept Oral Pathol, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliationPathol Aracatuba Pathol Inst, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Dent, Dept Infantile & Social Dent, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Vet Med, Dept Anim Hlth & Prod, São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Sch Dent, Postgrad Program, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent, Dept Oral Pathol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Med, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent, Dept Infantile & Social Dent, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Vet Med, Dept Anim Hlth & Prod, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sch Dent, Postgrad Program, São Paulo, Brazil
dc.format.extent593-598
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0714.2008.00704.x
dc.identifier.citationJournal of Oral Pathology & Medicine. Malden: Wiley-blackwell, v. 37, n. 10, p. 593-598, 2008.
dc.identifier.doi10.1111/j.1600-0714.2008.00704.x
dc.identifier.issn0904-2512
dc.identifier.lattes4146341015030248
dc.identifier.urihttp://hdl.handle.net/11449/42174
dc.identifier.wosWOS:000259866600004
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Oral Pathology & Medicine
dc.relation.ispartofjcr2.237
dc.relation.ispartofsjr0,791
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjecthuman papillomavirusen
dc.subjectpolymerase chain reactionen
dc.subjectsquamous cell carcinomaen
dc.titleDetection of HPV in mouth floor squamous cell carcinoma and its correlation with clinicopathologic variables, risk factors and survivalen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes4146341015030248
unesp.author.orcid0000-0002-5748-9412[6]
unesp.author.orcid0000-0002-9914-1000[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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