Ionotropic glutamatergic receptors in the rostral medullary raphe modulate hypoxia and hypercapnia-induced hyperpnea

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dc.contributor.authorNucci, Tatiane B.
dc.contributor.authorDias, Mirela Barros
dc.contributor.authorBranco, Luiz G. S.
dc.contributor.authorGargaglioni, Luciane H. [UNESP]
dc.contributor.institutionSt Josephs Hosp
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:15:41Z
dc.date.available2014-05-20T13:15:41Z
dc.date.issued2011-01-31
dc.description.abstractIt has been suggested that the medullary raphe (MR) plays a key role in the physiological responses to hypoxia and hypercapnia. We assessed the role of ionotropic glutamate receptors in the rostral MR (rMR) in the respiratory responses to hypoxia and hypercapnia by measuring pulmonary ventilation (V(E)) and body temperature (Tb) of male Wistar rats before and after microinjecting Kynurenic acid (KY, an ionotropic glutamate receptors antagonist, 0.1 mM) into the rMR followed by 60 min of hypoxia (7% O(2)) or hypercapnia exposure (7% CO(2)). Compared to the control group, the ventilatory response to hypoxia was attenuated in animals treated with KY intra-rMR, however the ventilatory response to hypercapnia increased significantly. No differences in Tb among groups were observed during hypoxia or hypercapnia. These data suggest that the glutamate acting on ionotropic receptors in the rMR exerts an excitatory modulation on hyperventilation induced by hypoxia but an inhibitory modulation on the hypercapnia-induced hyperpnea. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationSt Josephs Hosp, Syst Inflammat Lab, Phoenix, AZ USA
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Physiol Sci, Goiania, Go, Brazil
dc.description.affiliationUniv São Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, BR-05508 São Paulo, Brazil
dc.description.affiliationUNESP, FCAV, Dept Anim Morphol & Physiol, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespUNESP, FCAV, Dept Anim Morphol & Physiol, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipPrograma de Apoio aos Núcleos de Excelência (PRONEX)
dc.format.extent104-111
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2010.09.015
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 175, n. 1, p. 104-111, 2011.
dc.identifier.doi10.1016/j.resp.2010.09.015
dc.identifier.issn1569-9048
dc.identifier.lattes3203493045928389
dc.identifier.orcid0000-0002-4084-3139
dc.identifier.urihttp://hdl.handle.net/11449/2760
dc.identifier.wosWOS:000286540900013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectVentilationen
dc.subjectRapheen
dc.subjectGlutamateen
dc.subjectHypoxiaen
dc.subjectHypercapniaen
dc.titleIonotropic glutamatergic receptors in the rostral medullary raphe modulate hypoxia and hypercapnia-induced hyperpneaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes3203493045928389
unesp.author.orcid0000-0002-4084-3139
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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