Gastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rul

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dc.contributor.authorBatista, Leônia Maria
dc.contributor.authorde Almeida, Ana Beatriz Albino
dc.contributor.authorLima, Gedson Rodrigues de Morais
dc.contributor.authorFalcão, Heloina de Sousa
dc.contributor.authorFerreira, Anderson Luiz
dc.contributor.authorMagri, Luciana de Pietro
dc.contributor.authorCoelho, Roberta Gomes [UNESP]
dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorBrito, Alba Regina Monteiro Souza
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:27:33Z
dc.date.available2014-05-27T11:27:33Z
dc.date.issued2013-01-01
dc.description.abstractSyngonanthus bisulcatus Rul., popularly known in Brazil as sempre-vivas chapadeira, is a plant of the family Eriocaulaceae, it is found in the states of Minas Gerais and Bahia. In this work, the ethanolic extract (EtOHE), flavonoid-rich (FRF), and flavonoid-deficient (FDF) fractions obtained from scapes of S. bisulcatus were investigated for gastroprotection in both rats and mice. The activity was evaluated in models for induced gastric ulcer (absolute ethanol, stress, non-steroidal anti-inflammatory drugs, and pylorus ligation). The participation of mucus and prostaglandin E2 were also investigated. Sb-EtOHE (50, 100, and 250 mg/kg, p.o.), Sb-FRF (100 mg/kg, p.o.), and Sb-FDF (100 mg/kg, p.o.) significantly reduced gastric injuries in all models. Sb-FRF altered gastric juice parameters after pylorus ligation. Sb-FRF and Sb-FDF (100 mg/kg each, p.o.) significantly increased the amount of adherent mucus in the gastric mucosa. Sb-FRF maintained the mucosal levels of prostaglandin after the administration of indomethacin. The results indicate that Sb-EtOHE, Sb-FRF and Sb-FDF have significant gastroprotective activity. The observed gastroprotective effects of S. bisulcatus probably involve the participation of both mucus and prostaglandins, integral parts of the gastrointestinal mucosa's cytoprotective mechanisms against aggressive factors. © 2013 Reproduction is free for scientific studies.en
dc.description.affiliationDepartamento de Ciências Farmacêuticas Centro de Ciências da Saúde Universidade Federal da Paraíba (UFPB), João Pessoa, PB
dc.description.affiliationDepartamento de Fisiologia e Biofísica Instituto de Biologia Universidade Estadual de Campinas (UNICAMP), Cx. Postal 6109, CEP. 13083-970, Campinas, SP
dc.description.affiliationDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP
dc.description.affiliationUnespDepartamento de Química Orgânica Instituto de Química Universidade Estadual Paulista (UNESP), Araraquara, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent35-44
dc.identifierhttp://www.acgpubs.org/RNP/2013/Volume7/Abstracts%207.1/5-RNP-1206-102.htm
dc.identifier.citationRecords of Natural Products, v. 7, n. 1, p. 35-44, 2013.
dc.identifier.file2-s2.0-84870387349.pdf
dc.identifier.issn1307-6167
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-84870387349
dc.identifier.urihttp://hdl.handle.net/11449/74321
dc.identifier.wosWOS:000319555200005
dc.language.isoeng
dc.relation.ispartofRecords of Natural Products
dc.relation.ispartofjcr1.311
dc.relation.ispartofsjr0,517
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectEriocaulaceae
dc.subjectGastric ulcer
dc.subjectGastroprotective activity
dc.subjectMedicinal plants
dc.subjectSyngonanthus bisulcatus
dc.subjectantiulcer agent
dc.subjectcimetidine
dc.subjectlansoprazole
dc.subjectplant extract
dc.subjectprostaglandin E2
dc.subjectSyngonanthus bisulcatus extract
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug dose comparison
dc.subjectdrug effect
dc.subjectdrug efficacy
dc.subjectdrug mechanism
dc.subjectdrug screening
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectphytochemistry
dc.subjectrat
dc.subjectstomach juice
dc.subjectstomach mucosa
dc.subjectstomach protection
dc.subjectstomach ulcer
dc.subjectMus
dc.subjectRattus
dc.subjectSyngonanthus
dc.titleGastroprotective effect of the ethanolic extract and fractions obtained from syngonanthus bisulcatus Rulen
dc.typeArtigo
dcterms.licensehttp://www.acgpubs.org/RNP/
unesp.author.orcid0000-0003-3032-2556[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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