Synergetic effect of silver nanoparticles and thiram on lipid bilayers

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dc.contributor.authorMartin, Cibely S. [UNESP]
dc.contributor.authorOliveira, Marcelo J.S. [UNESP]
dc.contributor.authorMaximino, Mateus D. [UNESP]
dc.contributor.authorPazin, Wallance M. [UNESP]
dc.contributor.authorConstantino, Carlos J.L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-05-01T11:54:11Z
dc.date.available2022-05-01T11:54:11Z
dc.date.issued2022-02-15
dc.description.abstractThe excessive concentration of nanomaterials and pesticides in industrial products, food, and in the environment can be a risk to human health. Exposure to these materials can occur through inhalation, dermal contact, or oral ingestion, which depends directly on the type of products we are exposed to. Extensive studies about the individual action of these compounds have been described. However, the effect of these mixtures (nanoparticles and pesticides, for instance) requires more investigation. Here, we evaluated by phase-contrast microscopy the individual and mixture effects of silver nanoparticles (AgNp) and thiram pesticide on mimetic systems of the lipid bilayer structure of the plasma membrane using DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) giant unilamellar vesicles (GUVs). Besides, the effect of thiram pesticide on DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) multilamellar vesicles containing AgNp (encapsulated) was also evaluated by surface-enhanced Raman scattering (SERS). The results showed a synergetic effect of the AgNp and thiram mixture, which lead to a loss of phase contrast intensity and rupture of the lipid bilayers. The synergetic effect was ascribed to the strong interaction AgNp-thiram through Ag-S bond formation.en
dc.description.affiliationSão Paulo State University (UNESP) School of Technology and Applied Sciences
dc.description.affiliationSão Carlos Institute of Physics Universityof São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Technology and Applied Sciences
dc.identifierhttp://dx.doi.org/10.1016/j.molliq.2021.118406
dc.identifier.citationJournal of Molecular Liquids, v. 348.
dc.identifier.doi10.1016/j.molliq.2021.118406
dc.identifier.issn0167-7322
dc.identifier.scopus2-s2.0-85122217037
dc.identifier.urihttp://hdl.handle.net/11449/233960
dc.language.isoeng
dc.relation.ispartofJournal of Molecular Liquids
dc.sourceScopus
dc.subjectLipid bilayer
dc.subjectSilver nanoparticles
dc.subjectThiram
dc.subjectVesicles
dc.titleSynergetic effect of silver nanoparticles and thiram on lipid bilayersen
dc.typeArtigo

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Artigos - Física, Química e Biologia - FCT