Pharmaceutical emulsions: a new approach for gene therapy

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dc.contributor.authorVerissimo, Lourena Mafra
dc.contributor.authorAgnez Lima, Lucymara Fassarela
dc.contributor.authorMonte Egito, Lucila Carmem
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.authorTabosa do Egito, E. Socrates
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:24:51Z
dc.date.available2014-05-20T13:24:51Z
dc.date.issued2010-06-01
dc.description.abstractThe concept of gene therapy involves the experimental transfer of a therapeutic gene into an individual's cells and tissues to replace an abnormal gene aiming to treat a disease, or to use the gene to treat a disease just like a medicine, improving the clinical status of a patient. The achievement of a foreigner nucleic acid into a population of cells requires its transfer to the target. Therefore, it is essential to create carriers (vectors) that transfer and protect the nucleic acid until it reaches the target. The obvious disadvantages of the use of viral vectors have directed the research for the development of a nonviral organized system such as emulsions. In fact, recently, there has been an increase of interest in its use in biotechnology as a nonviral vector for gene therapy. This review focuses on the progress of cationic emulsions and the improvement of the formulations, as a potential delivery system for gene therapy.</.en
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), LASID, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUniversidade Federal do Rio Grande do Norte (UFRN), Dept Biol Celular & Genet, LBMG, Ctr Biociencias, Natal, RN, Brazil
dc.description.affiliationUNESP, Fac Ciencias Farmaceut, Dept Farm & Medicamentos, Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Farmaceut, Dept Farm & Medicamentos, Araraquara, SP, Brazil
dc.format.extent333-342
dc.identifierhttp://dx.doi.org/10.3109/10611860903434019
dc.identifier.citationJournal of Drug Targeting. London: Informa Healthcare, v. 18, n. 5, p. 333-342, 2010.
dc.identifier.doi10.3109/10611860903434019
dc.identifier.issn1061-186X
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/7818
dc.identifier.wosWOS:000277364900001
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofJournal of Drug Targeting
dc.relation.ispartofjcr3.408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectCationic emulsionsen
dc.subjectgene transfectionen
dc.subjectgene therapyen
dc.subjectcarrier systemsen
dc.subjectdelivery systemsen
dc.titlePharmaceutical emulsions: a new approach for gene therapyen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/page/resources/authors
dcterms.rightsHolderInforma Healthcare
unesp.author.lattes9114495952533044[4]
unesp.author.orcid0000-0002-2180-3991[5]
unesp.author.orcid0000-0003-0642-3162[2]
unesp.author.orcid0000-0002-9289-0455[1]
unesp.author.orcid0000-0002-0107-9940[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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