Gentamicin encapsulated within a biopolymer for the treatment of Staphylococcus aureus and Escherichia coli infected skin ulcers

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dc.contributor.authorGemeinder, José Lúcio Pádua [UNESP]
dc.contributor.authorBarros, Natan Roberto de [UNESP]
dc.contributor.authorPegorin, Giovana Sant’Ana [UNESP]
dc.contributor.authorSingulani, Junya de Lacorte [UNESP]
dc.contributor.authorBorges, Felipe Azevedo [UNESP]
dc.contributor.authorArco, Marina Constante Gabriel Del
dc.contributor.authorGiannini, Maria José Soares Mendes [UNESP]
dc.contributor.authorAlmeida, Ana Marisa Fusco [UNESP]
dc.contributor.authorSalvador, Sérgio Luiz de Souza
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2020-12-12T02:22:13Z
dc.date.available2020-12-12T02:22:13Z
dc.date.issued2020-01-01
dc.description.abstractSkin wound infection requires carefully long-term treatment with an immense financial burden to healthcare systems worldwide. Various strategies such as drug delivery systems using polymer matrix from natural source have been used to enhance wound healing. Natural rubber latex (NRL) from Hevea brasiliensis has shown angiogenic and tissue repair properties. Gentamicin sulfate (GS) is a broad-spectrum antibiotic which inhibits the growth of a wide variety of microorganisms and, because of this, it has also been applied topically for treatment of local infections. The aim of this study was to develop a GS release system using NRL as matrix for Staphylococcus aureus and Escherichia coli infected skin ulcers treatment, without changing drug antibiotic properties. The matrix did not change the GS antimicrobial activity against S. aureus and E. coli strains. Moreover, the NRL-GS biomembrane did not exhibit hemolytic activity, being non-toxic to red blood cells. The eluates of NRL-GS biomembranes and GS solutions did not significantly reduce the survival of Caenorhabditis elegans worms for 24 h at any of the tested concentrations. Thus, these results emphasize that the NRL-GS biomembrane proved to be a promising biomaterial for future studies on the development of dressings for topical uses, inexpensive and practicable, keeping drug antibiotic properties against pathogens and to reduce the side effects.en
dc.description.affiliationDepartment of Biotechnology São Paulo State University (UNESP) School of Sciences Humanities and Languages
dc.description.affiliationDepartment of Biochemistry and Chemical Technology São Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationDepartment of Clinical Toxicological and Bromatological Analysis São Paulo University (USP) School of Pharmaceutical Sciences
dc.description.affiliationUnespDepartment of Biotechnology São Paulo State University (UNESP) School of Sciences Humanities and Languages
dc.description.affiliationUnespDepartment of Biochemistry and Chemical Technology São Paulo State University (UNESP) Institute of Chemistry
dc.description.affiliationUnespDepartment of Biotechnology and Bioprocesses Engineering São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.description.affiliationUnespDepartment of Clinical Analysis São Paulo State University (UNESP) School of Pharmaceutical Sciences
dc.identifierhttp://dx.doi.org/10.1080/09205063.2020.1817667
dc.identifier.citationJournal of Biomaterials Science, Polymer Edition.
dc.identifier.doi10.1080/09205063.2020.1817667
dc.identifier.issn1568-5624
dc.identifier.issn0920-5063
dc.identifier.scopus2-s2.0-85090456458
dc.identifier.urihttp://hdl.handle.net/11449/201024
dc.language.isoeng
dc.relation.ispartofJournal of Biomaterials Science, Polymer Edition
dc.sourceScopus
dc.subjectantimicrobial activity
dc.subjectBiomembrane
dc.subjectCaenorhabditis elegans
dc.subjectdressing
dc.subjectgentamicin
dc.subjecthemolysis
dc.titleGentamicin encapsulated within a biopolymer for the treatment of Staphylococcus aureus and Escherichia coli infected skin ulcersen
dc.typeArtigo
unesp.author.orcid0000-0003-3817-8202[3]

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Artigos - Bioquímica e Tecnologia - IQ
Artigos - Análises Clínicas - FCFAR