Rabies laboratory diagnosis: Peculiar features of samples from equine origin

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dc.contributor.authorPeixoto, ZMP
dc.contributor.authorCunha, EMS
dc.contributor.authorSacramento, DRV
dc.contributor.authorSouza, MCAM
dc.contributor.authorSilva, LHQ da
dc.contributor.authorGermano, P. L.
dc.contributor.authorKroeff, S. S.
dc.contributor.authorKotait, I
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-10T18:00:39Z
dc.date.available2020-12-10T18:00:39Z
dc.date.issued2000-01-01
dc.description.abstractRabies laboratory diagnosis is performed by using microscopic examination for Negri bodies (MEN), fluorescent-antibody test (FAT) and mouse inoculation test (MIT). In the majority of cases, when specimens are properly collected and conserved and the laboratory worker has good experience, agreement among employed techniques is verified. Comparing the sensitivity of these three diagnosis techniques in 3,713 samples (hippocampus and brain stem) received during 1981-1994 period, being 3,010 from bovine (983 positives) and 703 from equine (Ill positives) species, it was observed that in equine rabid samples, this agreement was not maintained. For the latter specie, only in few opportunities the Negri bodies could be observed. With respect to FAT, the test detected a lower percentage of positive equine samples compared to bovine species. Statistical analysis demonstrated that the difference was significative. Mouse inoculation test proved to be more sensitive. However, a significant difference in mice incubation period was observed for samples from both species. The absence of inclusion bodies and the longer incubation period for equine samples suggest that rabies pathogenesis studies for equine species have to be intensified.en
dc.description.affiliationInst Biol, Lab Raiva & Encefalites Virais, Secao Raiva & Encefalomielite, BR-04014001 Sao Paulo, Brazil
dc.description.affiliationInst Biol, Lab Reg Pindamonhangaba, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Apoio Prod & Saude Anim, Aracatuba, SP, Brazil
dc.description.affiliationUniv Sao Paulo, Fac Saude Publ, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Apoio Prod & Saude Anim, Aracatuba, SP, Brazil
dc.format.extent72-75
dc.identifier.citationBrazilian Journal Of Microbiology. Sao Paulo: Soc Brasileira Microbiologia, v. 31, n. 1, p. 72-75, 2000.
dc.identifier.issn1517-8382
dc.identifier.urihttp://hdl.handle.net/11449/195701
dc.identifier.wosWOS:000165675900016
dc.language.isoeng
dc.publisherSoc Brasileira Microbiologia
dc.relation.ispartofBrazilian Journal Of Microbiology
dc.sourceWeb of Science
dc.subjectequine rabies
dc.subjectlaboratory diagnosis
dc.titleRabies laboratory diagnosis: Peculiar features of samples from equine originen
dc.typeArtigo
dcterms.rightsHolderSoc Brasileira Microbiologia

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