Circulating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsia

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dc.contributor.authorSandrim, Valeria [UNESP]
dc.contributor.authorCoeli-Lacchini, Fernanda Borchers
dc.contributor.authorTanus-Santos, Jose Eduardo
dc.contributor.authorLacchini, Riccardo
dc.contributor.authorCavalli, Ricardo Carvalho
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T16:19:52Z
dc.date.available2019-10-06T16:19:52Z
dc.date.issued2019-04-03
dc.description.abstractObjectives: We aimed to assess the plasma HO-1 level and its interrelationship with the plasma sFLT-1 level in preeclamptic and healthy pregnant women with different variants of microsatellite polymorphism (GTn) located in the promoter region of the HMOX-1 gene. Methods: HO-1 and sFLT-1 were measured by ELISA. HMOX1 genotyping was performed using fragment analysis. Results: We found similar and higher levels of plasma HO-1 and sFLT-1, respectively, in preeclampsia. Similar genotypes and alleles frequencies were found in both groups and the absence of modulation of HO-1 levels by genotypes were observed. Conclusion: The plasma HO-1 levels are not increased in preeclampsia women and neither related to sFLT-1 levels and GT n polymorphism.en
dc.description.affiliationDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.description.affiliationDepartments of Internal Medicine Ribeirao Preto College of Nursing University of Sao Paulo
dc.description.affiliationDepartments of Pharmacology Ribeirao Preto College of Nursing University of Sao Paulo
dc.description.affiliationDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto College of Nursing University of Sao Paulo
dc.description.affiliationDepartments of Gynecology and Obstetrics Faculty of Medicine of Ribeirao Preto Ribeirao Preto College of Nursing University of Sao Paulo
dc.description.affiliationUnespDepartment of Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP)
dc.format.extent73-77
dc.identifierhttp://dx.doi.org/10.1080/10641955.2019.1582664
dc.identifier.citationHypertension in Pregnancy, v. 38, n. 2, p. 73-77, 2019.
dc.identifier.doi10.1080/10641955.2019.1582664
dc.identifier.issn1525-6065
dc.identifier.issn1064-1955
dc.identifier.scopus2-s2.0-85062514252
dc.identifier.urihttp://hdl.handle.net/11449/188808
dc.language.isoeng
dc.relation.ispartofHypertension in Pregnancy
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectHMOX1 genotyping
dc.subjectoxidative stress
dc.subjectplasma HO-1
dc.subjectplasma sFLT-1
dc.subjectpolymorphism
dc.subjectPreeclampsia
dc.titleCirculating HO-1 levels are not associated with plasma sFLT-1 and GT n HMOX1 polymorphism in preeclampsiaen
dc.typeArtigo

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