Development and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drug

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dc.contributor.authorRolfsen Ferreira da Silva, Gisela Bevilacqua [UNESP]
dc.contributor.authorScarpa, Maria Virginia [UNESP]
dc.contributor.authorRossanezi, Gustavo [UNESP]
dc.contributor.authorTabosa do Egito, Eryvaldo Socrates
dc.contributor.authorOliveira, Anselmo Gomes de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal do Rio Grande do Norte (UFRN)
dc.date.accessioned2014-12-03T13:11:43Z
dc.date.available2014-12-03T13:11:43Z
dc.date.issued2014-01-01
dc.description.abstractMicroemulsions (MEs) are colloidal systems that can be used for drug-delivery and drug-targeting purposes. These systems are able to incorporate drugs modifying bioavailability and stability and reducing toxic effects. The jasmonate compounds belong to a group of plant stress hormones, and the jasmonic acid and its methyl ester derivative have been described as having anticancer activity. However, these compounds are very poorly water-soluble, not allowing administration by an intravenous route without an efficient nanostructured carrier system. In this work, biocompatible MEs of appropriate diameter size for intravenous route administration, loaded and unloaded with methyl dihydrojasmonate (MJ), were developed and described in a pseudo-ternary phase diagram. The compositions of the MEs were carefully selected from their own regions in the pseudo-ternary phase diagram. The formulations were analyzed by light scattering, polarized light microscopy, and X-ray diffraction. Also, a study on rheological profile was performed. The results showed that the droplet size decreased with both MJ incorporation and oil phase/surfactant ratio. All compositions of the studied MEs showed rheological behavior of pseudoplastic fluid and amorphous structures. In the absence of MJ, most of the studied MEs had thixotropic characteristics, which became antithixotropic in the presence of the drug. Almost all MJ-unloaded MEs presented anisotropic characteristics, but some formulations became isotropic, especially in the presence of MJ. The results of this study support the conclusion that the studied system represents a promising vehicle for in vivo administration of the MJ antitumor drug.en
dc.description.affiliationUniv Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUniv Fed Rio Grande do Norte UFRN, Lab Sistemas Dispersos, Natal, RN, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent867-876
dc.identifierhttp://dx.doi.org/10.2147/IJN.S46055
dc.identifier.citationInternational Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 867-876, 2014.
dc.identifier.doi10.2147/IJN.S46055
dc.identifier.fileWOS000331040500001.pdf
dc.identifier.issn1178-2013
dc.identifier.lattes9114495952533044
dc.identifier.urihttp://hdl.handle.net/11449/113464
dc.identifier.wosWOS:000331040500001
dc.language.isoeng
dc.publisherDove Medical Press Ltd
dc.relation.ispartofInternational Journal of Nanomedicine
dc.relation.ispartofjcr4.370
dc.relation.ispartofsjr1,225
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectmethyl dihydrojasmonateen
dc.subjectanticancer drugen
dc.subjectbiocompatible microemulsionsen
dc.subjectpseudo-ternary phase diagramen
dc.subjectmicroemulsion characterizationen
dc.titleDevelopment and characterization of biocompatible isotropic and anisotropic oil-in-water colloidal dispersions as a new delivery system for methyl dihydrojasmonate antitumor drugen
dc.typeArtigo
dcterms.rightsHolderDove Medical Press Ltd
unesp.author.lattes9114495952533044[5]
unesp.author.orcid0000-0002-0107-9940[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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