Growth factors and glucose homeostasis in diabetic rats: effects of exercise training

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dc.contributor.authorGomes, Ricardo Jose [UNESP]
dc.contributor.authorCuriacos de Almeida Leme, Jose Alexandre [UNESP]
dc.contributor.authorde Moura, Leandro Pereira [UNESP]
dc.contributor.authorde Araujo, Michel Barbosa [UNESP]
dc.contributor.authorRogatto, Gustavo Puggina [UNESP]
dc.contributor.authorde Moura, Rodrigo Ferreira [UNESP]
dc.contributor.authorLuciano, Eliete [UNESP]
dc.contributor.authorRostom de Mello, Maria Alice [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:48:41Z
dc.date.accessioned2014-05-20T13:58:25Z
dc.date.available2013-09-30T18:48:41Z
dc.date.available2014-05-20T13:58:25Z
dc.date.issued2009-06-01
dc.description.abstractTo investigate the alterations of glucose homeostasis and variables of the insulin-like growth factor-I (IGF- 1) growth system in sedentary and trained diabetic (TD) rats, Wistar rats were divided into sedentary control (SC), trained control (TC), sedentary diabetic (SD), and TD groups. Diabetes was induced by Alloxan (35 mg kg(-1) b.w.). Training program consisted of swimming 5 days week(-1), 1 h day(-1), during 8 weeks. Rats were sacrificed and blood was collected for determinations of serum glucose, insulin, growth hormone (GH), IGF-1, and IGF binding protein-3(IGFBP-3). Muscle and liver were removed to evaluate glycogen content. Cerebellum was extracted to determinate IGF-1 content. Diabetes decreased serum GH, IGF-1, IGFBP-3, liver glycogen, and cerebellum IGF-1 peptide content in baseline condition. Physical training recovered liver glycogen and increased serum and cerebellum IGF-1 peptide in diabetic rats. Physical training induces important metabolic and hormonal alterations that are associated with an improvement in glucose homeostasis and serum and cerebellum IGF-1 concentrations. Copyright (C) 2009 John Wiley & Sons, Ltd.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Phys Educ, Rio Claro, SP, Brazil
dc.format.extent199-204
dc.identifierhttp://dx.doi.org/10.1002/cbf.1556
dc.identifier.citationCell Biochemistry and Function. Chichester: John Wiley & Sons Ltd, v. 27, n. 4, p. 199-204, 2009.
dc.identifier.doi10.1002/cbf.1556
dc.identifier.issn0263-6484
dc.identifier.lattes2933779830637191
dc.identifier.urihttp://hdl.handle.net/11449/20754
dc.identifier.wosWOS:000267149900004
dc.language.isoeng
dc.publisherJohn Wiley & Sons Ltd
dc.relation.ispartofCell Biochemistry and Function
dc.relation.ispartofjcr2.186
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiabetesen
dc.subjectglucose homeostasisen
dc.subjectinsulin-like growth factor-Ien
dc.subjecttrainingen
dc.titleGrowth factors and glucose homeostasis in diabetic rats: effects of exercise trainingen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderJohn Wiley & Sons Ltd
unesp.author.lattes2933779830637191
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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