Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestris

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dc.contributor.authorCorsino, J.
dc.contributor.authorde Carvalho, PRF
dc.contributor.authorKato, M. J.
dc.contributor.authorLatorre, L. R.
dc.contributor.authorOliveira, OMMF
dc.contributor.authorAraújo, Angela Regina [UNESP]
dc.contributor.authorBolzani, Vanderlan da Silva [UNESP]
dc.contributor.authorFranca, S. C.
dc.contributor.authorPereira, AMS
dc.contributor.authorFurlan, Maysa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Ribeirao Preto
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)
dc.date.accessioned2014-05-20T15:28:40Z
dc.date.available2014-05-20T15:28:40Z
dc.date.issued2000-12-01
dc.description.abstractMaytenus aquifolium (Celastraceae) and Salacia campestris (Hippocrateaceae) species accumulate friedelane and quinonemethide triterpenoids in their leaves and root bark, respectively. Enzymatic extracts obtained from leaves displayed cyclase activity with conversion of the substrate oxidosqualene to the triterpenes, 3 beta -friedelanol and friedelin. In addition, administration of (+/-)5-H-3 mevalonolactone in leaves of M. aquifolium seedlings produced radio labelled friedelin in the leaves, twigs and stems, while the root bark accumulated labelled maytenin and pristimerin. These experiments indicated that the triterpenes once biosynthesized in the leaves are translocated to the root bark and further transformed to the antitumoral quinonemethide triterpenoids. (C) 2000 Elsevier B.V. Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, BR-05599970 São Paulo, Brazil
dc.description.affiliationUniv Ribeirao Preto, Dept Biotecnol, BR-14096380 Ribeirao Preto, Brazil
dc.description.affiliationUniv Ribeirao Preto, Dept Biotecnol, BR-14096380 Ribeirao Preto, SP, Brazil
dc.description.affiliationUFMS, CCBS, Dept Morfol, BR-79070900 Campo Grande, MS, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, BR-14801970 Araraquara, SP, Brazil
dc.format.extent741-748
dc.identifierhttp://dx.doi.org/10.1016/S0031-9422(00)00285-5
dc.identifier.citationPhytochemistry. Oxford: Pergamon-Elsevier B.V., v. 55, n. 7, p. 741-748, 2000.
dc.identifier.doi10.1016/S0031-9422(00)00285-5
dc.identifier.issn0031-9422
dc.identifier.lattes0037579054083160
dc.identifier.lattes4484083685251673
dc.identifier.lattes1308042794786872
dc.identifier.orcid0000-0001-7616-9652
dc.identifier.urihttp://hdl.handle.net/11449/38438
dc.identifier.wosWOS:000165994900008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPhytochemistry
dc.relation.ispartofjcr3.186
dc.relation.ispartofsjr1,048
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMaytenus aquifoliumpt
dc.subjectCelastraceaept
dc.subjectSalacia campestrispt
dc.subjectHippocrateaceaept
dc.subjectfriedelanespt
dc.subjectquinonemethidespt
dc.subjectoxidosqualenept
dc.subjectcyclase activitypt
dc.subject(+/-)S-H-3-mevalonolactonept
dc.subjectbiosynthesispt
dc.titleBiosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestrisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0037579054083160[6]
unesp.author.lattes4484083685251673
unesp.author.lattes1308042794786872
unesp.author.orcid0000-0001-7616-9652[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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