NuBBEDB: An updated database to uncover chemical and biological information from Brazilian biodiversity

dc.contributor.authorPilon, Alan C. [UNESP]
dc.contributor.authorValli, Marilia [UNESP]
dc.contributor.authorDametto, Alessandra C. [UNESP]
dc.contributor.authorPinto, Meri Emili F. [UNESP]
dc.contributor.authorFreire, Rafael T.
dc.contributor.authorCastro-Gamboa, Ian [UNESP]
dc.contributor.authorAndricopulo, Adriano D.
dc.contributor.authorBolzani, Vanderlan S. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:13:50Z
dc.date.available2018-12-11T17:13:50Z
dc.date.issued2017-12-01
dc.description.abstractThe intrinsic value of biodiversity extends beyond species diversity, genetic heritage, ecosystem variability and ecological services, such as climate regulation, water quality, nutrient cycling and the provision of reproductive habitats it is also an inexhaustible source of molecules and products beneficial to human well-being. To uncover the chemistry of Brazilian natural products, the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) was created as the first natural product library from Brazilian biodiversity. Since its launch in 2013, the NuBBEDB has proven to be an important resource for new drug design and dereplication studies. Consequently, continuous efforts have been made to expand its contents and include a greater diversity of natural sources to establish it as a comprehensive compendium of available biogeochemical information about Brazilian biodiversity. The content in the NuBBEDB is freely accessible online (https://nubbe.iq.unesp.br/portal/nubbedb.html) and provides validated multidisciplinary information, chemical descriptors, species sources, geographic locations, spectroscopic data (NMR) and pharmacological properties. Herein, we report the latest advancements concerning the interface, content and functionality of the NuBBEDB. We also present a preliminary study on the current profile of the compounds present in Brazilian territory.en
dc.description.affiliationNuclei of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University - UNESP
dc.description.affiliationCentro de Imagens e Espectroscopia in Vivo Por Ressonância Magnética Institute of Physics of Sao Carlos University of Sao Paulo - USP
dc.description.affiliationLaboratório de Química Medicinal e Computacional (LQMC) Centro de Pesquisa e Inovação em Biodiversidade EFármacos Institute of Physics of Sao Carlos University of Sao Paulo - USP
dc.description.affiliationUnespNuclei of Bioassays Biosynthesis and Ecophysiology of Natural Products (NuBBE) Department of Organic Chemistry Institute of Chemistry Sao Paulo State University - UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifierhttp://dx.doi.org/10.1038/s41598-017-07451-x
dc.identifier.citationScientific Reports, v. 7, n. 1, 2017.
dc.identifier.doi10.1038/s41598-017-07451-x
dc.identifier.file2-s2.0-85026852865.pdf
dc.identifier.issn2045-2322
dc.identifier.scopus2-s2.0-85026852865
dc.identifier.urihttp://hdl.handle.net/11449/175009
dc.language.isoeng
dc.relation.ispartofScientific Reports
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleNuBBEDB: An updated database to uncover chemical and biological information from Brazilian biodiversityen
dc.typeArtigo

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