Grafts of porcine small intestinal submucosa seeded with cultured homologous smooth muscle cells for bladder repair in dogs

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dc.contributor.authorRossetto, Victor J. V. [UNESP]
dc.contributor.authorMota, Ligia S. L. S. da [UNESP]
dc.contributor.authorRocha, Noeme Sousa [UNESP]
dc.contributor.authorMiot, Helio A. [UNESP]
dc.contributor.authorGrandi, Fabrizio [UNESP]
dc.contributor.authorBrandão, Claudia Valeria Seullner [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-12-03T13:10:37Z
dc.date.available2014-12-03T13:10:37Z
dc.date.issued2013-05-07
dc.description.abstractBackground: Due to numerous complications associated to gastrointestinal augmented cystoplasty, this study aimed to analyze the anatomic repair of the bladder of 10 female dogs using grafts of porcine small intestinal submucosa (SIS) seeded with cultured homologous smooth muscle cells, and compare them with the acellular SIS grafts.Results: We assessed the possible side effects and complications of each type of graft by clinical examination, abdominal ultrasound and laboratory findings. Anatomic repair of neoformed bladder was assessed by histological staining for H/E and Masson's Trichrome, analyzed with a Nikon Photomicroscope connected to the system of image analysis Image J.Conclusions: We propose that SIS associated to homologous smooth cells can improve the quality of tissue repair, and consequently decrease the potential complications inherent to acellular SIS.en
dc.description.affiliationSao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Clin, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Sch Med, Dept Dermatol & Radiotherapy, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationSao Paulo State Univ UNESP, Dept Genet, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Surg & Anesthesiol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Clin, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Med, Dept Dermatol & Radiotherapy, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Dept Genet, Inst Biosci, BR-18618970 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent6
dc.identifierhttp://dx.doi.org/10.1186/1751-0147-55-39
dc.identifier.citationActa Veterinaria Scandinavica. London: Biomed Central Ltd, v. 55, 6 p., 2013.
dc.identifier.doi10.1186/1751-0147-55-39
dc.identifier.fileWOS000319465800001.pdf
dc.identifier.issn0044-605X
dc.identifier.lattes6077735918469284
dc.identifier.lattes1087615389013655
dc.identifier.orcid0000-0002-8188-8149
dc.identifier.orcid0000-0002-2011-5214
dc.identifier.urihttp://hdl.handle.net/11449/112324
dc.identifier.wosWOS:000319465800001
dc.language.isoeng
dc.publisherBiomed Central Ltd.
dc.relation.ispartofActa Veterinaria Scandinavica
dc.relation.ispartofjcr1.497
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTissue reconstructionen
dc.subjectBioengineered tissueen
dc.subjectCell therapyen
dc.subjectSISen
dc.titleGrafts of porcine small intestinal submucosa seeded with cultured homologous smooth muscle cells for bladder repair in dogsen
dc.typeArtigo
dcterms.rightsHolderBiomed Central Ltd
unesp.author.lattes6077735918469284
unesp.author.lattes1087615389013655[6]
unesp.author.orcid0000-0003-4513-753X[2]
unesp.author.orcid0000-0001-7693-8108[1]
unesp.author.orcid0000-0002-2596-9294[4]
unesp.author.orcid0000-0002-8188-8149
unesp.author.orcid0000-0002-2011-5214[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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