Exercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic rats

Página do item simplificado
dc.contributor.authorClaudino, Mario A.
dc.contributor.authorDelbin, Maria A. [UNESP]
dc.contributor.authorFranco-Penteado, Carla F.
dc.contributor.authorPriviero, Fernanda B. [UNESP]
dc.contributor.authorDe Nucci, Gilberto
dc.contributor.authorAntunes, Edson
dc.contributor.authorZanesco, Angelina [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:25:27Z
dc.date.available2014-05-27T11:25:27Z
dc.date.issued2011-01-31
dc.description.abstractAims: The effect of exercise training (ET) on vascular responsiveness in diabetes mellitus has been largely well studied. However, limited studies have investigated the effects of ET on functional responses of the corpus cavernosum (CC) in diabetic animals. Therefore, the aim of this study was to investigate whether prior ET prevents the impairment of erectile function in streptozotocin-induced diabetic rats. Main methods: Rats were exercised for four weeks prior to the induction of diabetes, and then again for another 4 weeks thereafter. Concentration-response curves to acetylcholine, sodium nitroprusside, Y-27632, BAY 412272 and phenylephrine (PE) were obtained in CC. The excitatory and inhibitory effects of electrical-field stimulation were also evaluated. Key findings: Plasma SOD levels were markedly decreased in the sedentary diabetic group (D-SD) as compared to control sedentary animals (C-SD), approximately 53% (P < 0.05) and this reduction was restored in trained diabetic animals. Physical training restored the impairment of endothelium-dependent and -independent relaxation responses seen in the D-SD group. The potency values for Y-27632 in the CC were significantly reduced in the D-SD group, which was reversed by physical training. The impairment of electrical-field stimulation (EFS)-induced relaxation seen in the D-SD group was restored by physical training. On the other hand, both EFS-induced contractions and concentration-response curves to PE in cavernosal strips were not modified by either diabetes or physical training. Significance: Practice of regular physical exercise may be an important approach in preventing erectile dysfunction associated with diabetes mellitus by re-establishment of the balance between NO production and its inactivation. © 2010 Elsevier Inc. All rights reserved.en
dc.description.affiliationDepartment of Pharmacology Faculty of Medical Sciences University of Campinas (UNICAMP), Campinas (SP)
dc.description.affiliationDepartment of Physical Education Institute of Bioscience UNESP, 13506-900 Rio Claro (SP)
dc.description.affiliationHematology and Hemotherapy Center Faculty of Medical Sciences University of Campinas (UNICAMP), PO Box 6111, 13084-971, Campinas (SP)
dc.description.affiliationUnespDepartment of Physical Education Institute of Bioscience UNESP, 13506-900 Rio Claro (SP)
dc.format.extent272-277
dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2010.11.018
dc.identifier.citationLife Sciences, v. 88, n. 5-6, p. 272-277, 2011.
dc.identifier.doi10.1016/j.lfs.2010.11.018
dc.identifier.file2-s2.0-78751647073.pdf
dc.identifier.issn0024-3205
dc.identifier.lattes4472007237545596
dc.identifier.scopus2-s2.0-78751647073
dc.identifier.urihttp://hdl.handle.net/11449/72300
dc.language.isoeng
dc.relation.ispartofLife Sciences
dc.relation.ispartofjcr3.234
dc.relation.ispartofsjr1,071
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCorpus cavernosum
dc.subjectDiabetes
dc.subjectPhysical training
dc.subjectSuperoxide dismutase
dc.subject4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide
dc.subject4 amino 5 cyclopropyl 2 [1 (2 fluorobenzyl) 1h pyrazolo[3,4 b]pyridin 3 yl]pyrimidine
dc.subjectacetylcholine
dc.subjectnitric oxide
dc.subjectnitroprusside sodium
dc.subjectphenylephrine
dc.subjectsuperoxide dismutase
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectblood vessel reactivity
dc.subjectcontrolled study
dc.subjectcorpus cavernosum
dc.subjectdiabetes mellitus
dc.subjectelectrostimulation
dc.subjecterectile dysfunction
dc.subjectexercise
dc.subjectmale
dc.subjectnitrergic nerve
dc.subjectnonhuman
dc.subjectrat
dc.subjectsmooth muscle relaxation
dc.subjectstreptozocin diabetes
dc.subjectvascular endothelium
dc.subjectAnimals
dc.subjectCells, Cultured
dc.subjectDiabetes Mellitus, Experimental
dc.subjectErectile Dysfunction
dc.subjectMale
dc.subjectMuscle Contraction
dc.subjectMuscle, Smooth
dc.subjectPenile Erection
dc.subjectPhysical Conditioning, Animal
dc.subjectRats
dc.subjectAnimalia
dc.subjectRattus
dc.titleExercise training ameliorates the impairment of endothelial and nitrergic corpus cavernosum responses in diabetic ratsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes4472007237545596
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

Arquivos

Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
2-s2.0-78751647073.pdf
Tamanho:
414.23 KB
Formato:
Adobe Portable Document Format
Descrição:
Baixar

Coleções

Artigos - Educação Física - IBRC