Impact of VDR and RXR expression in non-melanoma skin cancer pathogenesis

Página do item simplificado
dc.contributor.authorOcanha-Xavier, Juliana P. [UNESP]
dc.contributor.authorXavier, José C. C. [UNESP]
dc.contributor.authorGuimarães da Silva, Márcia [UNESP]
dc.contributor.authorMarques, Mariângela E. A. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPrivate Clinic (JPOX Clinic)
dc.contributor.institutionAraçatuba Institute of Pathology
dc.contributor.institutionUnisalesiano
dc.date.accessioned2022-04-29T08:46:49Z
dc.date.available2022-04-29T08:46:49Z
dc.date.issued2022-01-01
dc.description.abstract1,25(OH)2D3, the active form of vitamin D, has been extensively studied for its putative protective activities against tumors. It does biological work by connecting to a nuclear receptor called VDR, which heterodimerizes itself to another nuclear receptor, RXR. The study observed differences in VDR and RXR expression in non-melanoma skin cancer a actinic keratosis and compared it with normal skin. We performed VDR and RXR immunohistochemistry of 76 controls (normal skin), 49 actinic keratosis, 99 basal cell carcinomas and 96 squamous cell carcinomas from formalin-fixed paraffin-embedded, resulting from surgical procedures. There was a clear pattern in the control group (p < 0.001), with the positivity of both receptors, VDR and RXR. Actinic keratosis differed from the basal cell carcinoma and control groups concerning RXR expression (p < 0.001). SCC was negative for both receptors, differing in all groups (p < 0.001). The site of positivity (nuclear, cytoplasmatic or both) of VDR differed between all groups (p < 0.001). To date, our series is the largest of VDR and RXR immunohistochemistry concerning non-melanoma skin cancer. Our findings reinforce the need to understand the pathways involving VDR and RXR to direct therapies and prevention manoeuvres.en
dc.description.affiliationDepartment of Pathology São Paulo State University UNESP
dc.description.affiliationPrivate Clinic (JPOX Clinic)
dc.description.affiliationAraçatuba Institute of Pathology
dc.description.affiliationSalesiano “Auxilium” Catholic University Center Faculty of Medicine Unisalesiano
dc.description.affiliationUnespDepartment of Pathology São Paulo State University UNESP
dc.identifierhttp://dx.doi.org/10.1111/exd.14574
dc.identifier.citationExperimental Dermatology.
dc.identifier.doi10.1111/exd.14574
dc.identifier.issn1600-0625
dc.identifier.issn0906-6705
dc.identifier.scopus2-s2.0-85127770176
dc.identifier.urihttp://hdl.handle.net/11449/231653
dc.language.isoeng
dc.relation.ispartofExperimental Dermatology
dc.sourceScopus
dc.subjectactinic
dc.subjectbasal cell
dc.subjectcalcitriol
dc.subjectcarcinoma
dc.subjectkeratosis
dc.subjectreceptors
dc.subjectretinoid X receptor alpha
dc.subjectsquamous cell
dc.titleImpact of VDR and RXR expression in non-melanoma skin cancer pathogenesisen
dc.typeArtigo
unesp.author.orcid0000-0002-1200-3730[1]
unesp.author.orcid0000-0003-0503-419X[2]
unesp.author.orcid0000-0002-4663-7926[3]
unesp.author.orcid0000-0001-6947-5627[4]

Arquivos

Coleções

Artigos - Patologia e Propedêutica Clínica - FOA