Avaliação do potencial cancerígeno do Diuron [3-(3,4-Diclorofenil)-1,1-Dimetiluréia] no modelo de iniciação-promoção cutânea em camundongos swiss

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dc.contributor.advisorCarmargo, João Lauro Viana de [UNESP]
dc.contributor.advisorOliveira, Deilson Elgui de [UNESP]
dc.contributor.authorFerrucio, Bianca [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-06-11T19:27:55Z
dc.date.available2014-06-11T19:27:55Z
dc.date.issued2010-01-03
dc.description.abstractDiuron [3-(3,4-dichlorophenyl)-1,1-dimethyl urea] is a herbicide with carcinogenic activity in rats and mice which have developed respectively urothelial and mammary gland tumors in long-term studies. Accordingly, diuron has been categorized as a “likely human carcinogen” by the USEPA. Although the carcinogenesis initiating activity of diuron has been reported in an early initiation-promotion mouse skin study, its genotoxic potential has been disputed. It is necessary to clarify the mode of action through which it has caused rodent neoplasia and verify its relevance to humans. Herein, two experiments were developed to verify the initiating and promoting potentials of diuron in a 23- and a 21-week long mouse skin carcinogenesis protocol. In one, dimethylsulphoxide (DMSO) was the solvent for the herbicide; in the other, acetone was the alternative solvent in order to verify if DMSO had inhibitory influence on a potential cutaneous carcinogenic activity. The adopted schedule for the tumor promoting agent 12-O-tetradecanoylphorbol 13-acetate (TPA) resulted in skin ulcers, evidencing the need for careful selection of TPA dose levels and frequency of application in this model. In both studies diuron did not exert any influence on the skin carcinogenesis process, in contrast with results already reported in the literature.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipToxicam
dc.format.extent47 f.
dc.identifier.aleph000611656
dc.identifier.capes33004064056P5
dc.identifier.citationFERRUCIO, Bianca. Avaliação do potencial cancerígeno do Diuron [3-(3,4-Diclorofenil)-1,1-Dimetiluréia] no modelo de iniciação-promoção cutânea em camundongos swiss. 2010. 47 f. Dissertação (mestrado) - Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, 2010.
dc.identifier.fileferrucio_b_me_botfm.pdf
dc.identifier.lattes5240998569868081
dc.identifier.urihttp://hdl.handle.net/11449/95844
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectHerbicidaspt
dc.subjectCarcinogenos - estudos experimentaispt
dc.subjectDiuronen
dc.subjectHerbicideen
dc.titleAvaliação do potencial cancerígeno do Diuron [3-(3,4-Diclorofenil)-1,1-Dimetiluréia] no modelo de iniciação-promoção cutânea em camundongos swisspt
dc.typeDissertação de mestrado
unesp.author.lattes5240998569868081
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt
unesp.graduateProgramPatologia - FMBpt
unesp.knowledgeAreaPatologiapt
unesp.researchAreaCarcinogênese cutânea experimentalpt

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