Intermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intake

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dc.contributor.authorOliveira, Luciana da Costa
dc.contributor.authorMorais, Gustavo Paroschi
dc.contributor.authorde Oliveira, Franciane Pereira
dc.contributor.authorMata, Milene Montavoni
dc.contributor.authorVeras, Allice Santos Cruz [UNESP]
dc.contributor.authorda Rocha, Alisson Luiz
dc.contributor.authorElias, Lucila Leico Kagohara
dc.contributor.authorTeixeira, Giovana Rampazzo [UNESP]
dc.contributor.authorde Moraes, Camila
dc.contributor.authorCintra, Dennys E.
dc.contributor.authorRopelle, Eduardo R.
dc.contributor.authorde Moura, Leandro P.
dc.contributor.authorPauli, José R.
dc.contributor.authorde Freitas, Ellen C.
dc.contributor.authorRorato, Rodrigo
dc.contributor.authorda Silva, Adelino Sanchez R.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2023-07-29T14:02:03Z
dc.date.available2023-07-29T14:02:03Z
dc.date.issued2023-09-01
dc.description.abstractHigh-fat diet consumption causes hypothalamic inflammation, dysregulating the leptin pathway, which, in turn, compromises the modulation of hypothalamic neuronal activities and predisposes obesity development. Intermittent fasting (IF) and exercise training (ET) have been demonstrated as efficient interventions to modulate hypothalamic inflammation and neuronal activity. However, no studies have evaluated whether combining these interventions could induce better results in reestablishing hypothalamic homeostasis disrupted by high-fat diet intake. The 8-week-old male C57BL/6 mice were randomly assigned into 2 groups: sedentary mice fed a standard diet (CT), and sedentary mice fed a high-fat diet (HF). After 8 weeks of an HF diet, part of the HF group (now 16 weeks old) was randomly subjected to different interventions for 6 weeks: HF-IF = HF diet mice submitted to IF; HF-T = HF diet mice submitted to ET; HF-IFT = HF diet mice submitted to IF and ET. All interventions decreased the body weight gain induced by high-fat diet intake, associated with reduced calorie consumption in week 14. Only the HF-IFT group presented improved serum insulin, leptin, resistin, and Tnf-alpha levels concomitantly with decreased hypothalamic inflammation. The HF-IFT group also demonstrated increased Pomc mRNA expression associated with enhanced pSTAT3 expression in the hypothalamic arcuate and ventromedial hypothalamic nuclei. Our data indicate that the beneficial effects of the combination of IF and ET on energy homeostasis are associated with increased leptin sensitivity in the hypothalamic arcuate nucleus and ventromedial hypothalamic nucleus, which is likely due to an improvement in hypothalamic inflammatory pathways in these nuclei.en
dc.description.affiliationPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School University of São Paulo (USP)
dc.description.affiliationLaboratory of Stress Neuroendocrinology Department of Biophysics Paulista Medical School Federal University of Sao Paulo, SP
dc.description.affiliationDepartament of Physiology Ribeirão Preto Medical School University of São Paulo
dc.description.affiliationMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP), SP
dc.description.affiliationDepartment of Physical Education Faculty of Technology and Sciences São Paulo State University (UNESP), SP
dc.description.affiliationSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationLaboratory of Molecular Biology of Exercise (LaBMEx) School of Applied Sciences University of Campinas (UNICAMP) Limeira
dc.description.affiliationDepartment of Health Sciences Ribeirão Preto Medical School University of São Paulo (USP), São Paulo
dc.description.affiliationUnespMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP), SP
dc.description.affiliationUnespDepartment of Physical Education Faculty of Technology and Sciences São Paulo State University (UNESP), SP
dc.identifierhttp://dx.doi.org/10.1016/j.jnutbio.2023.109372
dc.identifier.citationJournal of Nutritional Biochemistry, v. 119.
dc.identifier.doi10.1016/j.jnutbio.2023.109372
dc.identifier.issn1873-4847
dc.identifier.issn0955-2863
dc.identifier.scopus2-s2.0-85160243725
dc.identifier.urihttp://hdl.handle.net/11449/249088
dc.language.isoeng
dc.relation.ispartofJournal of Nutritional Biochemistry
dc.sourceScopus
dc.subjectHypothalamus
dc.subjectIntermittent fasting
dc.subjectLeptin
dc.subjectObesity
dc.subjectPhysical exercise
dc.titleIntermittent fasting combined with exercise training reduces body mass and alleviates hypothalamic disorders induced by high-fat diet intakeen
dc.typeArtigo
unesp.author.orcid0000-0001-7725-0161[1]
unesp.author.orcid0000-0002-3460-6970[2]
unesp.author.orcid0000-0002-5414-3280[3]
unesp.author.orcid0000-0002-6703-8113[5]
unesp.author.orcid0000-0002-4133-8353[6]
unesp.author.orcid0000-0002-6271-758X[7]
unesp.author.orcid0000-0002-7954-5630[10]
unesp.author.orcid0000-0002-1327-9501[15]
unesp.author.orcid0000-0002-9679-8357 0000-0002-9679-8357[16]

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