Use of animals in dental research: Trends and ethical reflections

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dc.contributor.authorLopes, Camila Soares [UNESP]
dc.contributor.authorFernandes, Clemente Maia S [UNESP]
dc.contributor.authorBarbosa, Aline Cristina S [UNESP]
dc.contributor.authorSerra, Mônica da Costa [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2023-03-02T10:07:06Z
dc.date.available2023-03-02T10:07:06Z
dc.date.issued2022-01-01
dc.description.abstractThis study aimed to survey and analyze the profile of experimental dental research in animals, verifying its trends. We evaluated studies developed with the use of animals in vivo, published in 10 dental journals with high impact factors, from 2015 to 2020. From 1652 studies retrieved, 594 involved in vivo experimentation on animals and were analyzed further. Rats were the species most used and with the highest mean of animals per study. Ferrets, although presenting the lowest rate of publications, had the second highest mean of animals per study. Periodontics was the dental specialty with the highest number of publications, while oral rehabilitation had the lowest number. The data on the institution responsible for reviewing animal research protocols approval, sample size, anesthesia and analgesia were provided in 93.10%, 83%, 70.54% and 23.74% of studies, respectively. In 53% of studies, euthanasia was specified and anesthetic overdose was the method most used. Over the period analyzed, there was a reduction in animal studies in vivo, and periodontics was the specialty that most used this experimental model. Although most studies mentioned approval by an ethics committee, some publications neglected to mention sample size, anesthesia and euthanasia. The omission of essential information may raise scientific and ethical concerns.en
dc.description.affiliationDepartment of Restorative Dentistry School of Dentistry São Paulo State University – Unesp
dc.description.affiliationDepartment of Community Dentistry School of Dentistry São Paulo State University – Unesp
dc.description.affiliationUnespDepartment of Restorative Dentistry School of Dentistry São Paulo State University – Unesp
dc.description.affiliationUnespDepartment of Community Dentistry School of Dentistry São Paulo State University – Unesp
dc.identifierhttp://dx.doi.org/10.1177/00236772221115488
dc.identifier.citationLaboratory Animals.
dc.identifier.doi10.1177/00236772221115488
dc.identifier.issn1758-1117
dc.identifier.issn0023-6772
dc.identifier.scopus2-s2.0-85135901858
dc.identifier.urihttp://hdl.handle.net/11449/242148
dc.language.isoeng
dc.relation.ispartofLaboratory Animals
dc.sourceScopus
dc.subjectAnimal experimentation
dc.subjectanimal use
dc.subjectbioethics
dc.subjectdental research
dc.subjectethics
dc.titleUse of animals in dental research: Trends and ethical reflectionsen
dc.typeArtigo
unesp.author.orcid0000-0001-8820-2982[4]

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Artigos - Odontologia Social - FOAR