ARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsia

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dc.contributor.authorLuizon, Marcelo R.
dc.contributor.authorPinto-Souza, Caroline C. [UNESP]
dc.contributor.authorCoeli-Lacchini, Fernanda
dc.contributor.authorLacchini, Riccardo
dc.contributor.authorCavalli, Ricardo C.
dc.contributor.authorSandrim, Valeria C. [UNESP]
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2023-03-01T21:11:49Z
dc.date.available2023-03-01T21:11:49Z
dc.date.issued2022-08-01
dc.description.abstractAim: This work examined whether ARG1 (rs2781659, rs2781667, rs2246012 and rs17599586) and ARG2 (rs3742879 and rs10483801) single-nucleotide polymorphisms (SNPs) are associated with antihypertensive therapy responsiveness in preeclampsia (PE) and their effects on arginase isoforms and nitrite concentrations in responsive and nonresponsive patients. Methods: SNP genotypes were determined by TaqMan assays. Plasma arginase levels were measured by ELISA and nitrite concentrations were measured using an ozone-based chemiluminescence assay. Results: The G allele for ARG2 rs3742879 (A>G) was less frequent in nonresponsive compared with responsive patients (15.5% vs 24.7%, respectively) and the G carriers of the nonresponsive subgroup had lower arginase 2 (9.2 ± 7.5 ng/ml vs 19.1 ± 17.3 ng/ml) and higher nitrite concentrations (110.2 ± 52.8 nM vs 78.5 ± 37.9 nM) than carriers of the AA genotype (all p < 0.05). Conclusion: ARG2 SNP rs3742879 is associated with diminished arginase 2 levels and increased nitric oxide formation in nonresponsive PE patients.en
dc.description.affiliationDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG), MG
dc.description.affiliationDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior, Botucatu
dc.description.affiliationDepartment of Clinical Analyses Toxicology and Food Science School of Pharmaceutical Sciences of Ribeirao Preto University of Sao Paulo (USP), Ribeirao Preto
dc.description.affiliationDepartment of Psychiatric Nursing and Human Sciences Ribeirao Preto School of Nursing University of Sao Paulo (USP), Ribeirao Preto
dc.description.affiliationDepartment of Gynecology and Obstetrics University of Sao Paulo (USP), Ribeirao Preto
dc.description.affiliationUnespDepartment of Biophysics and Pharmacology Institute of Biosciences of Botucatu Universidade Estadual Paulista (UNESP), Distrito Rubiao Junior, Botucatu
dc.format.extent713-722
dc.identifierhttp://dx.doi.org/10.2217/pgs-2022-0079
dc.identifier.citationPharmacogenomics, v. 23, n. 13, p. 713-722, 2022.
dc.identifier.doi10.2217/pgs-2022-0079
dc.identifier.issn1744-8042
dc.identifier.issn1462-2416
dc.identifier.scopus2-s2.0-85137134448
dc.identifier.urihttp://hdl.handle.net/11449/241589
dc.language.isoeng
dc.relation.ispartofPharmacogenomics
dc.sourceScopus
dc.subjectARG2
dc.subjectarginase 2
dc.subjectgenetic polymorphisms
dc.subjecthypertension
dc.subjectnitric oxide
dc.subjectnitrite
dc.subjectpharmacogenetics
dc.subjectpreeclampsia
dc.titleARG2 single-nucleotide polymorphism rs3742879 affects plasma arginase 2 levels, nitric oxide formation and antihypertensive therapy response in preeclampsiaen
dc.typeArtigo
unesp.author.orcid0000-0002-8331-3525[1]
unesp.author.orcid0000-0002-6168-7470[6]

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