Cytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materials

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dc.contributor.authorDo Amaral Escada, Ana Lúcia [UNESP]
dc.contributor.authorCamargo, Samira Esteves Afonso [UNESP]
dc.contributor.authorDe Vasconcellos, Luana Marotta Reis [UNESP]
dc.contributor.authorMilhan, Noala Vicensoto Moreira [UNESP]
dc.contributor.authorClaro, Ana Paula Rosifini Alves [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:34:51Z
dc.date.available2018-12-11T17:34:51Z
dc.date.issued2017-11-01
dc.description.abstractTitanium (Ti) and its alloys are widely used for medical and dental fields due to their excellent biocompatibility, high corrosion resistance, high specific strength and excellent mechanical properties. Different methods have been developed to improve the surface properties of titanium-based implant materials, and consequently the bone-bonding ability. The Ti-7.5Mo alloy was activated by an alkaline treatment with 5M NaOH, heat treatment and subsequent immersion in SBFx5 to investigate the in vitro response of osteoblastic-like cells (MG-63) on altered biomimetic surfaces. Sample surfaces were characterized by scanning electron microscopy. Cytotoxicity was assessed by the MTT assay, total protein content, alkaline phosphatase activity (ALP) and mineralized bone-like nodule formation. It was shown the que alkali treatment led to the formation of sodium titanate and immersion in SBFx5 formed a film of calcium phosphate. The alkaline treatment and heat treatment of 7.5 Ti-Mo alloys followed by soaking them in SBFx5 for 24 hours is a suitable technique once the final samples were biocompatible, allowed the attachment of the osteoblastic-like cells (MG-G3), and increased the mineralized like-bone nodules formation by these cells.en
dc.description.affiliationDepartamento de Materiais e Tecnologia Universidade Estadual Paulista -UNESP, Av. Dr. Ariberto Pereira da Cunha, 333
dc.description.affiliationDepartamento de Biociências e Diagnóstico Bucal Universidade Estadual Paulista -UNESP
dc.description.affiliationUniversidade Estadual Paulista -UNESP
dc.description.affiliationUnespDepartamento de Materiais e Tecnologia Universidade Estadual Paulista -UNESP, Av. Dr. Ariberto Pereira da Cunha, 333
dc.description.affiliationUnespDepartamento de Biociências e Diagnóstico Bucal Universidade Estadual Paulista -UNESP
dc.description.affiliationUnespUniversidade Estadual Paulista -UNESP
dc.format.extent1614-1621
dc.identifierhttp://dx.doi.org/10.1590/1980-5373-MR-2016-0268
dc.identifier.citationMaterials Research, v. 20, n. 6, p. 1614-1621, 2017.
dc.identifier.doi10.1590/1980-5373-MR-2016-0268
dc.identifier.fileS1516-14392017000601614.pdf
dc.identifier.issn1516-1439
dc.identifier.scieloS1516-14392017000601614
dc.identifier.scopus2-s2.0-85033707015
dc.identifier.urihttp://hdl.handle.net/11449/179356
dc.language.isoeng
dc.relation.ispartofMaterials Research
dc.relation.ispartofsjr0,398
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBiomimetic treatment
dc.subjectCytotoxicity
dc.subjectTitanium alloys
dc.titleCytotoxicity analysis of Ti-7.5Mo alloy after biomimetic surface treatment to use as dental materialsen
dc.typeArtigo
unesp.author.lattes2302418953025459[5]
unesp.author.orcid0000-0003-3353-4247[5]

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Artigos - Biociências e Diagnóstico Bucal - ICT
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