Consequences of the exposome to gestational diabetes mellitus

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dc.contributor.authorRudge, Marilza V.C. [UNESP]
dc.contributor.authorAlves, Fernanda C.B. [UNESP]
dc.contributor.authorHallur, Raghavendra L.S. [UNESP]
dc.contributor.authorOliveira, Rafael G. [UNESP]
dc.contributor.authorVega, Sofia [UNESP]
dc.contributor.authorReyes, David R.A. [UNESP]
dc.contributor.authorFloriano, Juliana F. [UNESP]
dc.contributor.authorPrudencio, Caroline B. [UNESP]
dc.contributor.authorGarcia, Gabriela A. [UNESP]
dc.contributor.authorReis, Fabiana V.D.S. [UNESP]
dc.contributor.authorEmanueli, Costanza
dc.contributor.authorFuentes, Gonzalo
dc.contributor.authorCornejo, Marcelo
dc.contributor.authorToledo, Fernando
dc.contributor.authorValenzuela-Hinrichsen, Andrés
dc.contributor.authorGuerra, Catalina
dc.contributor.authorGrismaldo, Adriana
dc.contributor.authorValero, Paola
dc.contributor.authorBarbosa, Angelica M.P. [UNESP]
dc.contributor.authorSobrevia, Luis [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionPravara Institute of Medical Sciences (DU)
dc.contributor.institutionImperial College London
dc.contributor.institutionUniversity Medical Center Groningen
dc.contributor.institutionUniversidad de Talca
dc.contributor.institutionUniversidad de Antofagasta
dc.contributor.institutionUniversidad del Bío-Bío
dc.contributor.institutionSchool of Medicine and Health Sciences
dc.contributor.institutionUniversidad de Sevilla
dc.contributor.institutionUniversity of Queensland
dc.contributor.institutionPontificia Universidad Católica de Chile
dc.date.accessioned2023-07-29T13:30:46Z
dc.date.available2023-07-29T13:30:46Z
dc.date.issued2023-02-01
dc.description.abstractThe exposome is the cumulative measure of environmental influences and associated biological responses throughout the lifespan, including those from the environment, diet, behaviour, and endogenous processes. The exposome concept and the 2030 Agenda for the Sustainable Development Goals (SDGs) from the United Nations are the basis for understanding the aetiology and consequences of non-communicable diseases, including gestational diabetes mellitus (GDM). Pregnancy may be developed in an environment with adverse factors part of the immediate internal medium for fetus development and the external medium to which the pregnant woman is exposed. The placenta is the interface between maternal and fetal compartments and acts as a protective barrier or easing agent to transfer exposome from mother to fetus. Under and over-nutrition in utero, exposure to adverse environmental pollutants such as heavy metals, endocrine-disrupting chemicals, pesticides, drugs, pharmaceuticals, lifestyle, air pollutants, and tobacco smoke plays a determinant role in the development of GDM. This phenomenon is worsened by metabolic stress postnatally, such as obesity which increases the risk of GDM and other diseases. Clinical risk factors for GDM development include its aetiology. It is proposed that knowledge-based interventions to change the potential interdependent ecto-exposome and endo-exposome could avoid the occurrence and consequences of GDM.en
dc.description.affiliationDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP), São Paulo
dc.description.affiliationCentre for Biotechnology Pravara Institute of Medical Sciences (DU), Loni-413736, Rahata Taluk, Ahmednagar District
dc.description.affiliationSão Paulo State University (UNESP) School of Sciences Postgraduate Program in Materials Science and Technology (POSMAT), São Paulo
dc.description.affiliationNational Heart and Lung Institute Imperial College London
dc.description.affiliationDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen
dc.description.affiliationFaculty of Health Sciences Universidad de Talca
dc.description.affiliationFaculty of Health Sciences Universidad de Antofagasta
dc.description.affiliationFaculty of Basic Sciences Universidad del Bío-Bío
dc.description.affiliationDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP), São Paulo
dc.description.affiliationTecnologico de Monterrey Eutra The Institute for Obesity Research (IOR) School of Medicine and Health Sciences, Nuevo León
dc.description.affiliationDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla
dc.description.affiliationUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland
dc.description.affiliationCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrician Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile
dc.description.affiliationUnespDepartment of Gynaecology and Obstetrics Botucatu Medical School São Paulo State University (UNESP), São Paulo
dc.description.affiliationUnespSão Paulo State University (UNESP) School of Sciences Postgraduate Program in Materials Science and Technology (POSMAT), São Paulo
dc.description.affiliationUnespDepartment of Physiotherapy and Occupational Therapy School of Philosophy and Sciences São Paulo State University (UNESP), São Paulo
dc.description.sponsorshipRijksuniversiteit Groningen
dc.description.sponsorshipPontificia Universidad Católica de Chile
dc.description.sponsorshipFondo Nacional de Desarrollo Científico y Tecnológico
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFondo Nacional de Desarrollo Científico y Tecnológico: 1190316
dc.description.sponsorshipIdFAPESP: 16/01743-5
dc.description.sponsorshipIdCNPq: 305116/2018-5
dc.identifierhttp://dx.doi.org/10.1016/j.bbagen.2022.130282
dc.identifier.citationBiochimica et Biophysica Acta - General Subjects, v. 1867, n. 2, 2023.
dc.identifier.doi10.1016/j.bbagen.2022.130282
dc.identifier.issn1872-8006
dc.identifier.issn0304-4165
dc.identifier.scopus2-s2.0-85142910183
dc.identifier.urihttp://hdl.handle.net/11449/247966
dc.language.isoeng
dc.relation.ispartofBiochimica et Biophysica Acta - General Subjects
dc.sourceScopus
dc.subjectbiomarkers
dc.subjectendogenous exposomes
dc.subjectenvironmental exposures
dc.subjectexposome
dc.subjectgestational diabetes
dc.titleConsequences of the exposome to gestational diabetes mellitusen
dc.typeResenha

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Artigos - Ginecologia e Obstetrícia - FMB
Artigos - Fisioterapia e Terapia Ocupacional - FFC