Leishmania hide-and-seek: Parasite amastigotes in the choroid plexus of a dog with neurological signs in an endemic municipality in Brazil

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dc.contributor.authorGrano, Fernanda Grecco [UNESP]
dc.contributor.authorSilva, José Eduardo dos Santos [UNESP]
dc.contributor.authorMelo, Guilherme Dias de
dc.contributor.authorMachado, Gisele Fabrino [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstitut Pasteur
dc.date.accessioned2019-10-06T17:08:27Z
dc.date.available2019-10-06T17:08:27Z
dc.date.issued2019-08-01
dc.description.abstractA female adult mixed-breed stray dog presented with hind limb paraparesis and clinical signs of visceral leishmaniasis. The cerebrospinal fluid presented signs of blood-brain barrier disruption. Both spleen and brain were positive for Leishmania spp. DNA. Besides inflammation, in situ hybridization and immunohistochemistry (IHC) revealed the presence of intracellular amastigotes in the choroid plexus (CP). Despite other studies that revealed parasite DNA, the current study describes the presence of Leishmania within the brain of a naturally infected dog, specifically in CP, with no previous reports in the Americas, and suggests the CP as a possible pathway to parasite entry into the brain.en
dc.description.affiliationFaculdade de Medicina Veterinária de Araçatuba UNESP - Univ Estadual Paulista, Rua Clóvis Pestana, 793
dc.description.affiliationLaboratoire des Processus Infectieux à Trypanosomatidés Département Infection et Epidemiologie Institut Pasteur, 25-28 Rue du Dr Roux
dc.description.affiliationUnespFaculdade de Medicina Veterinária de Araçatuba UNESP - Univ Estadual Paulista, Rua Clóvis Pestana, 793
dc.identifierhttp://dx.doi.org/10.1016/j.vprsr.2019.100291
dc.identifier.citationVeterinary Parasitology: Regional Studies and Reports, v. 17.
dc.identifier.doi10.1016/j.vprsr.2019.100291
dc.identifier.issn2405-9390
dc.identifier.scopus2-s2.0-85064981803
dc.identifier.urihttp://hdl.handle.net/11449/190293
dc.language.isoeng
dc.relation.ispartofVeterinary Parasitology: Regional Studies and Reports
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBrain
dc.subjectInflammation
dc.subjectLeishmaniasis, visceral
dc.subjectProtozoan infections
dc.titleLeishmania hide-and-seek: Parasite amastigotes in the choroid plexus of a dog with neurological signs in an endemic municipality in Brazilen
dc.typeArtigo

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Artigos - Clínica, Cirurgia e Reprodução Animal - FMVA